4.1 Allele, DQa Results

Nicole

5 Posts
Reply Posted on: Dec 31, 2013 at 1:06am
Hi Dr. Braverman,I recently had DQ Alpha testing done with my husband and although we are not an alpha match at all, I carry the 4.1 allele. I'm worried if this is a cause for concern as I have read through many sources that this genotype on it's own causes problems similar to a dq alpha match because it resembles cancer to the body, which can cause the immune attack / nk cell activity. I also know I have very high natural killer activity, so I am wondering if this is related. That said, Do we have the same prognosis a 50% dqa match couple would have? As 50% of our embryos would carry my 4.1?Also I see we share a partial Beta match and a few partial matches in the other HLA's, is this relevant at all?

Last question, promise! I have recently read my DRB1 0304 puts me at a very high risk of miscarriage. This is obviously devestating and was wondering if you had any thoughts on this? Our results:DQ Alpha
(ME) 3.1, 4.1
(DH) 1.3, 2.1DQ Beta
(ME) 02, 03
(DH) 03, 06HLA-A (ME) 02, 26
HLA-B (DH) 01, 24HLA-B (ME) 38, 47
HLA-B (DH) 08, 57HLA-C (ME) 07,12
HLA-C (DH) 06, 07HLA-DRB1 (ME) 03, 04, DRB3, DRB4
HLA-DRB1 (DH) 07, 13, DRB3, DRB4

Thank you in advance!!

Dr. Braverman

2026 Posts
RE: 4.1 Allele, DQa Results Posted on: Dec 31, 2013 at 6:45am
You have quite a bit of mis information and some correct conclusions but with the wrong inferences.

the idea of DQalpha matching or partial matching is very far outdated and not relevant .
You do not have any HLA matching issues. what you do have is combination of HLA genes that together form a haplotype called the 8.1 Haplotype which is responsible for 90% of all autoimmunity. That by itself can be a cause of recurrent pregnancy loss, but a more complete workup needs to be done.
With a correct diagnosis these issues can be treated.
I would be happy to assist you with this , simply fill out a consult request from our website.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Nicole

5 Posts
Reply RE: 4.1 Allele, DQa Results Posted on: Dec 31, 2013 at 1:03pm
Thank you for the quick response! Do you think the combination of intralipids, steroids and lovenox would be effective enough for this issue? I know you have had lots of success using Neupogen but I do not think my RE will prescribe it -- wondering if this is necessary for treatment of the 8.1 halotype.

Dr. Braverman

2026 Posts
RE: 4.1 Allele, DQa Results Posted on: Jan 2, 2014 at 6:53am
I would need to see more immune data to prescribe a treatment plan for you, as well as your complete clinical history . Treatments have to be tailored to all not just a few lab tests.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.