Adenomyosis / Natural Killer Cells


2 Posts
Reply Posted on: May 20, 2014 at 4:40am
Sorry, I have 2 questions here in one post. I have always had Adenomyosis and it has been breezed over in the past as not been an issue.

3 weeks ago I had my 2nd Egg donor cycle with 2 excellent blastocysts transferred (we used a sperm donor this time as well). I was on immune treatment which I would like to ask about as well, though my first quesiton is I have since learnt that adenomyoisis can be an issue and some doctors treat with a long down reg of 3 months on zoladex implants? I also have endo, though my last lap was 3 years ago where they saw some on the bowel as well, but I havent had treated to date. I have very painful pain on the r/hand side near my ovary, usually on the 1st day of my period and it only used to be at night, now it is duirng the day more often than not as well. My GP thought it could be endo on my bowel - but now I've heard it could be my adenomyosis causing the pain. There doesnt seem to be alot of information out there, hence why I am writing to you.

I have also been treating my Natural killer cells. For this cycle I was on 2 x 40mg Humira 2-3 months prior, 2 x LIT treatment with donor & my husband for the 2nd treatment, 15mg of Predsinone, 1000mg metformin, 60mg clexane daily and baby asprin. My NK Cells shot up to double after transfer which was end April and these results were from blood drawn 12 May 204.

NK 50:1 now 10.9 was 4.3 in Feb 2014
CD56 now 21.3 was 10.7 in Feb, and 15.5 with no meds
TNF Alpha: IL10 now 42.4 was 33.4 in Feb
IFNgamma:IL10 now 12.5 was 5.4 in Feb

We have 4 hatching blastocysts left and this will be our absolute last attempt ever.
My FS is unsure about other treatment such as IVIg due to my low IGAs - tested this week at:
IGA .55L (range .7-4.0)
IgC 5.54 (range 7.0-16.0)
IgM 1.53 (range 0.4-3.0)

I would really appreciate your advice as we have paid for both ED cycles on credit cards and immune treatment alone cost $6,000 on top. We really need to get this cycle right, or be told honeslty if it is not worth the risk with low IGAs, or if there is no other treatment avaialbe to treat such agressive natural killer cells?

Thanks very much for your time.

Dr. Braverman

2026 Posts
RE: Adenomyosis / Natural Killer Cells Posted on: May 20, 2014 at 6:30am
If you read my other posts you know that I dont treat symprotms (i.e. elevated NK cells) and also that pts with adenomyosis and endometriosis have an underlying autoimmune syndrome. In your case this needs to be diagnosed then we can discuss correct treatments for you. I would not proceed with any other transfers until this is done. I would be happy to assist you , simply fill out a consult request and we will schedule a free 10 minute chat to review your case.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.