Age 39, 1 pregnancy from the first attempt (lost unfortunately) and another 3 years with no other pregnancy


1 Posts
Reply Posted on: Jun 25, 2013 at 8:27am

We have read about your expertise in helping womens with immunologic related infertility and because of our history we have decided to ask you if you think you can help us.

We decided to ask you first of all if you think that you can help us, at least with a few advices, because we are from Europe (Romania) and because there is no chance for us to come to the US for consultation.

If you think that you can help us, please provide to us an email address where we can send a summary of our history and testing we have done so far.

Very short history of our infertility:

- 3 years ago (at the age of 35 years and 8 months), we have decided to make a baby and we have succeeded to get a pregnancy from the first attempt. The pregnancy had a placental abruption and presented blood cysts around the placenta. The pregnancy was lost after 10 weeks and had to be removed by curettage.

- after another 1,5 years of unsuccesfull attempts to conceive naturally we have realised that something bad has happened and we began testing, in an attempt to find the reason behind our infertility issue.

What we have learned so far:

- detected presence of an uterine synechiae related to the previous curettage. Today this problem is solved and verified again.

- left tubal oclusion. 10 months earlier, during histerosalpingography, both tubes were permeable;

- during the thrombophilia screening we have learned that there is a gene mutation called MTHFR C677T homozygous and quite low protein S activity;

- postcoital test negative, only 2-3 spermatozoa with normal mobility detected 10 hours after intercourse;

- Subclinical Hashimoto syndrome detected, presently under treatment with Euthyrox;

- the last two findings have lead us into the immunology area, where we have tested for NK cells count: the initial result was a huge dissapointment, we have found an astonishing 29% NK cells count.

- 1-2 months after finding high NK cells count, we have gone to Greece to investigate further the immune issue. We have found NK cells count to be 22,6% (no treatment to explain the difference between the 29% and 22,6% testing), Nk dim very high and NK bright very low. Th17 is also way out of the scale.

- KIR testing for intralipid: 8 out of 8 presence - no benefit to be expected from that treatment;

- KIR testing for neupogen: 4 out of 6 absent - might indicate medium response from a treatment using neupogen.

Right now we are attempting a treatment using: fish oil, vitamin D3, Vitamin C, prednolon and flixotide.

This is a short description of our problem, if you are willing to help, please let us know and we will send you a more complete and detailed version the treatments and of the analysis report we have so far.

Thank You.

Dr. Braverman

2026 Posts
RE: Age 39, 1 pregnancy from the first attempt (lost unfortunately) and another 3 years with no other pregnancy Posted on: Jun 25, 2013 at 8:38am
when trying to evaluate a case such as yours NK cells and KIR(ILs do not treat KIR mismatches) are helpful but by no means give the complete picture. It is so important to identify the reasons for these elevations (the IL17 included) so that you can prepare a more logical approach. Of course I would be willing to help you . Please fill out a consult request from the website and we can begin the process for you. I lood forward to speaking with you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.