Ankylosing Spondylitis (HLA-B27 +ve) and IVF/PGD


1 Posts
Reply Posted on: Jul 22, 2013 at 12:14am
I am 33 and have previously been diagnosed with AS and confirmed positive for HLA-B27 gene (although I am aware not all AS sufferers carry the gene so im not sure if that makes a difference in terms of fertility). I have 3 healthy sons and have also had 3 MC (at 10wks / 6wks / 5.5wks which were preg 1 / 2 / 5). I fall pregnant relatively quickly but whether I will stay pregnant is always the mystery.
I am considering IVF next year and am wondering what considerations I should be aware of. The disease is active at the moment but I do know that my diet / exercise has a big influence in controlling it. I am at a very healthy weight and if I diet strictly and exercise my weight only fluctuates by a maximum of 3 kg. I am not currently taking any medication other than paracetamol / ibuprofen as required. I am due to see my Rheumatolgist in a few weeks.

- Is there any difference whether my disease is active or not at the time of cycling?

- Should I expect to have fewer "normal" embryos for transfer?

- Is there anything I can do or supplements I can take to improve my chances of a successful transfer (aspirin??).

Any advice you could offer would be most appreciated.

Thankyou :)

Dr. Braverman

2026 Posts
RE: Ankylosing Spondylitis (HLA-B27 +ve) and IVF/PGD Posted on: Jul 22, 2013 at 6:05am
We have had success with AS . But of course you need to be sure it is the AS that is the problem (but I do think that is most likely). I would need to get testing on you to see where we would need to focus the treatments. I would want to look at cellular and antibody profiles on you as well as a complet cytokine profiel (serum and cellular). But Im sure I can at least give you answers. At that point I would be able to recommend supplements as well.
If you would like my help please fill out the consult form on our website.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.