Anti-E and Anti-Kell antibody

charisma

1 Posts
Reply Posted on: Jun 12, 2013 at 5:40pm
Dear Dr Braverman,

I am currently 10 weeks pregnant with my 3rd child. With my first 2 pregnancies I tested positive for the anti-Kell antibody. My husband was tested for the antigen and he was negative so we haven't worried about it, although it is strange that I had the antibody at all because I've never been exposed to any blood/blood products. The titer was always undetectable so we wondered if there was any cross-reactivity going on causing the positive test.

This pregnancy I noticed my lab work from when I was 5 weeks pregnant says I also have the anti-E antibody which I never had before. The titer is also undectable. Could I have the anti-E if one of my children has the antigen and I was exposed when I gave birth? If the titer is undetectable does that make it less likely to be a problem for this baby? Is anti-E as bad as some of the other Rh factors?

Dr. Braverman

2026 Posts
RE: Anti-E and Anti-Kell antibody Posted on: Jun 13, 2013 at 12:04pm
I think this question is best directed to a peri natalogist.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Lindsey L

4 Posts
RE: Anti-E and Anti-Kell antibody Posted on: Jul 20, 2013 at 5:25pm
Hello,
I recently found out that I am Anti Kell positive. Do you know if it can cause miscarriages? I have had two 6 months apart. I'm having trouble finding any info online. We haven't tested my husband yet but I had a blood transfusion 6 years ago after I had our daughter. So, we are thinking that's where I got it from. I hope your pregnancy is going well!

Dr. Braverman

2026 Posts
RE: Anti-E and Anti-Kell antibody Posted on: Jul 21, 2013 at 6:35pm
no these are not the cuases of your early miscarriages. I beleve you need to test your hsuband and if he is Kell neg homozygous then these are not of any conern.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Lindsey L

4 Posts
RE: Anti-E and Anti-Kell antibody Posted on: Jul 21, 2013 at 8:57pm
Thank you so much for your reply. I'm hoping to get my husband in to get tested this week.

Dr. Braverman

2026 Posts
RE: Anti-E and Anti-Kell antibody Posted on: Jul 22, 2013 at 6:05am
you are very welcome.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Lindsey L

4 Posts
RE: Anti-E and Anti-Kell antibody Posted on: Jul 25, 2013 at 6:47am
I had two miscarriages a year ago. And after my second one (a week later) I had blood work done and it came back that I had Anti Kell. But my levels of it were too weak to show up on the titer level. Well, here I am a year later and I had blood work done the other day and my blood showed negative for an antibody...NO kell. My OB says my blood is normal. Is that possible? Or if I get pregnant again will it come back?

Dr. Braverman

2026 Posts
RE: Anti-E and Anti-Kell antibody Posted on: Jul 25, 2013 at 7:03am
did you ever have a blood transfusion? If not then this may just be the levels dropping before a repeat expsoure would raise them. If you have had a blood product this could just be a transient anbibody.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Lindsey L

4 Posts
RE: Anti-E and Anti-Kell antibody Posted on: Jul 28, 2013 at 9:43pm
Yes. I've had a blood transfusion. What is a transient antibody, exactly? Is that possible to have happen with kell?

Thank you

Dr. Braverman

2026 Posts
RE: Anti-E and Anti-Kell antibody Posted on: Jul 29, 2013 at 5:59am
yes it can and is most likely the source of your antibody. again your husband should be checked for his Kell status and your pregnancies must be followed to be sure.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.