Bloods clotting or autoimmune questions


1 Posts
Reply Posted on: Mar 6, 2014 at 5:29pm
Here is my background:

I am 26, diagnosed with high prolactin and polycystic ovaries (but not hormonal issues related to the actual syndrome). My husband is 27 and diagnosed with low count and motility. We tried to conceive for a year before treatment

*IVF #1 (July '13): Transferred 1 embryo"- Success: Miscarried at 5 weeks (told it was just change/bad luck)
*FET #1 (Oct. '13): Developed a fever and unable to walk from progesterone in oil-diagnosed as an allergy. Switched to endometrin and proceeded with transfer of 1 embyro-Unsuccessful
*FET #2 (Dec. '13)-Transferred 2 embryos. Successful: One baby, saw the heartbeat 2 times before missed miscarriage at 8 weeks. *Chromosomes from D & C and Karotyping tests were both normal.
*FET #3 tentatively April 11th (pending results of recurrent miscarriage testing)

I got my test results from recurrent miscarriages and most things were fine. However, one thing was flagged as high according to lab corp. (0-12 is normal, 13-20 indeterminate and 20 and up is positive. Mine was 20. It is " Anticardiolipin Ab,IgM qn". Additionally, antibodies in bloodwork a few years ago (during a sickness) made my dr think that I have lupus. I went to a rhemutologist and he said no but my "Antiphosphatidylserine IgM" was 41 (I think normal was 20 or less). I get terrible migraines which I think it related to blood issues.

I was hoping dr. would call and say ok, it's going to be blood thinners with this next cycle, or at least aspirin due to the "low positive". Nope, he says the number is high but not high enough to treat. He doesn't think it's causing my miscarriages, he thinks it's just bad luck. He wants to proceed with transferring two more embryos. I asked him many times and told him I was worried-he said he didn't recommend treating it.

I'm so frustrated. I don't WANT something to be wrong with me, but at the same token....doesn't the quote go "The definition of insanity is doing the same thing over and over again and expecting different results."

I have a meeting with my regular ob/gyn on Tuesday to get her opinion and what else I should test for. Do you think I should hold off on another transfer and pursue more possible issues? For example, I asked them to test MTHFR mutation and they said it's not signficant and they don't do that. :o(

I'd like to hear your opinion about what you suggest. Thank you.

Dr. Braverman

2026 Posts
RE: Bloods clotting or autoimmune questions Posted on: Mar 6, 2014 at 8:18pm
Well it certainly sounds like there is an autoimmune component to your issues. The testing that you have had performed to date has been isolated, you need a complete immune profile so the correct treatments can be recommended. Although the antibodies you have may not have been signficant enought to diagnose an immune disease they do show a propensity for immune dysregulation of implantation and this is what needs to be diagnosed and treated.

I would be happy to assist you with this , just fill out a contact form from our website.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.