Can IVIG or prednisone treat highly elevated ANA?


5 Posts
Reply Posted on: Jun 2, 2013 at 10:14pm
Hi, Dr. Braverman:

My ANA is positive with a tier > 1:2560 and specked (I have sjogren syndrom and SSA is out of chart).

I heard prednisone is not effective for suppressing super high ANA.

Have you seen patients with such high ANAs and what drugs were effective?


Dr. Braverman

2026 Posts
RE: Can IVIG or prednisone treat highly elevated ANA? Posted on: Jun 3, 2013 at 6:24am
Yes I do think IVIG is effective as well as prednisone together.Studies have shown that IVIG actually potentiates the activity of prednisone. A recent study has shown that IVIG has many different concentrations of "active" antibodies, and in research labs that have the ability to test them, outcomes were significantly better in the group that had these higher levels , so I like to try and monitor the effect my looking at other paramters such as antibody levels in the maternal serum and other inflammatory markers.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.