Case Report success after 15 failed IVF cycles

Dr. Braverman

2026 Posts
Reply Case Report success after 15 failed IVF cycles Posted on: Sep 24, 2010 at 4:19pm
A case report has been published in a patient that had failed 15 IVF cycles 2 of them from donor egg and those were from different donors. She was found to have endometriosis , mild, but all other work up was normal.
For this cycle she was found to have elevated NK activity and NK numbers. These were corrected but the patient still failed her 14th and 15th IVF cycles. At this point Enoxapairn, (lovenox), viagra, and Etanercept(like Humira) was added and patient finally had a successful pregnancy.

It appears again that in cases of failed therapy , combination therapy that addresses clotting, uterine lining, and immune issues works better together when independantly they have failed.

We have had similar success in one of our patients that had failed 18 IVF cycles prior to contacting us , and also failed IVIG treatments. When we combined lovenox, intralipids and a new agent called Colony Granulocyte Stimulating Factor(a cytokine that assists with production of tolerogenic dendritic cells and cell proliferation) she has finally acheived success for the first time.

Combination therapy should not be the first line of attack with immune issues but does show benefit when there are failures as highlighted by these two cases that clearly had significant issues prior to treatement.
Braverman Medical Team
Braverman Reproductive Immunology P.C.

Andrea

0 Posts
Re: Case Report success after 15 failed IVF cycles Posted on: Oct 7, 2010 at 3:26pm
Hey Dr. Braverman!
Congratulations on the new website. It is very informative! I really enjoy reading all of your research oriented posts. I am curious why you posted that combination therapy should not be the first line of treatment. Doesn't it make sense to treat those issues before potential IVF/IUI failures? Why wait until someone has already had a failure to treat it? Is it that there are disadvantages to such an aggressive protocol?

Thanks!

Dr. Braverman

2026 Posts
Reply Re: Case Report success after 15 failed IVF cycles Posted on: Oct 7, 2010 at 11:31pm
Thanks Andrea

My comment applies to using the least 'invasive" measures first. Humira although being used now with greater frequency for elevated TNF has greater risks than the other treatments, so it should be added only when IVIG and prednisone fail. As far as the combination of conventional treatments I agreee there should be no waiting when they are necessary, Im referring to the addition of Humira or C-GSF. As you know we have used conventional combinations IVIG,prednisone,viagra,lovenox with great success with minimal risk. Hope that answers your question.
Braverman Medical Team
Braverman Reproductive Immunology P.C.

Vusypevussy

1 Posts
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