CGH normal embryo failed to implant

Hazel

2 Posts
Reply Posted on: Mar 24, 2015 at 11:40pm
Hi,

I got pregnant with my husband in 2009 accidently and electively terminated in 2 months. After which when we started trying in 2012 we were not having any success. In 2013 Jan I was pregnant naturally again but that was a chemical. The only thing that changed between 2009 and 2012 is I started having painful periods and doc saw what they felt were 2 big complex cysts.

Before they could do the lap the cyst shrunk.(Could endo shrink so quickly). My AMH came back very low and FSH high in 2013(Age 29) . But fortunately AFC was ok (around 12). After a failed IUI and failed IVF(that was definetely due to bad response and poor quality cos it was not the right protocol), I did another round with a CGH tested embryo which has failed.


I have elevated NK cells ~13/14% and 6 HLA matches (includes DQ alpha , HLA-A, HLA-C, DRB1 partial and DQ Beta complete)

I am wondering why I am having a complete implantation failure even with a CGH normal embryo. The CGH cycle was accompanied with Prednisone and Intralipid treatment.

1. Could DQ Beta complete match be of any significance?
2. I dont have painful periods for over 2 years now. Also my APA test came normal? Does it mean I dont have endometriosis

Any thoughts on why I might be having complete implantation failure and do you see cases like me? How difficult is it given according to you?
Hazel

Dr. Braverman

2026 Posts
RE: CGH normal embryo failed to implant Posted on: Mar 25, 2015 at 6:24am
Yes I see cases like you all the time. I think endometriosis and the underlying immune issues associated with it are playing a part. I would have to see all of your immune testing to give you an accurate diagnosis, but the matching on the class 1 HLA may actually be beneficial not harmful. I would suggest filling out a consult form on the webste and scheduling a frfee 10 minute chat.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Hazel

2 Posts
Reply RE: CGH normal embryo failed to implant Posted on: Mar 25, 2015 at 4:44pm
Thank you,
I am waiting for my first appointment with you on Apr 1, Meanwhile, for the benifit of others and self may I ask you the following:

If I do have to undergo a resective surgery, is there a healing period or can I try immeidately an FET (I have one more CGH normal embryo left) immediately the next month.

Do you expect the AMH to improve after surgery?

Can I use my existing CGH normal embryo again or need to produce new embryo in the healed environment

I keep hearing of "old endo". If the endo I have turns out to be old endo/scarring, is this surgically removable?

My husband has a complete DQ Beta match with me and also has a 02 in his own alpha and beta. The theory of blighted ovum with such a HLA is outdated. Am I right?


Lastly, I know Neupogen has helped many people with HLA matches, but does Neupogen help with complete immune rejection in endometriosis cases. What kind of success rates do you see.

Thank you,
Hazel
Hazel

Dr. Braverman

2026 Posts
RE: CGH normal embryo failed to implant Posted on: Mar 26, 2015 at 10:43am
there is no differnce between old endo and or new endo, they all act the same. Any embryo produced in the environment of endometriosis (even if CGH tested) do not give the same success as those made after surgery. However it does not mean this is a good embryo and you should always consider taking the "easiest" route to pregnancy i.e. FET with the old CGH embryo. The 02 DQbeta issues are old and outdated. We dont always see the AMH go back up but we do see better performance of the embryos post surgery. I prefer to wait 6 weeks prior to starting FET after the surgery for healing and inflammatory response of the surgery to go down.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.