Does elevated ANA affect follicle development?


5 Posts
Reply Posted on: Jun 3, 2013 at 9:47pm
Hi, Dr. Braverman:

I watched your video which discussed elevated ANA affect embryo development and lead to IVF implantation failures or recurrent losses.

I have more trouble with getting pregnant even I did have one miscarriage in last 2.5 years due to a chromosomal abnormality.

Will highly elevated ANA (e.g. tier of 1:2560) affect follicle development?

I heard from other REs, if a miscarriage is due to chromosomal abnormality, that means the egg quality is the cause of the miscarriage rather than autoimmue issues. Do you agree?

Since the eggs may not mature due to ANA or other autoimmune problem, will ANA+ affect both egg quality and quantity?
(POF seems to be related to autoimmune)

Any insight is highly appreciated!

Dr. Braverman

2026 Posts
RE: Does elevated ANA affect follicle development? Posted on: Jun 4, 2013 at 6:00am
A positive ANA is a marker that there is loss of immune regulation at some point. This can be associated with anti ovarian antibodies and POF. If there is a marked inllammatory response and there are elevated levels of inflammatory cells or cytokines in the folliclular fluid there have been reports that this can affect egg quality as well. Once an embryo or miscarriage is deemed to be chromosomally abnormal then that is the cause of the loss. I hope that helps.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.