HLA testing and neupogen treatment

clairl

3 Posts
Reply Posted on: Dec 10, 2013 at 12:41pm
Dear Dr Braverman

Can neupogen treat HLA matching?

My husband and I are not matches for the DQ Alpha but have not tested beyond this.

I have all 3 KIRs missing and so planned to use Neupogen on our next IVF. Could this also treat any HLA matches? if so is it a different regime with the neupogen for treating this as opposed to treating the missing KIRs? If we are having neupogen anyway do we need to test for further HLA matches?

Many thanksClair
clair lewoski

Dr. Braverman

2026 Posts
RE: HLA testing and neupogen treatment Posted on: Dec 10, 2013 at 2:51pm
I always recommend getting the full HLA testing as well as all of the other components on our full immune panel. Missing KIR is only one small piece of information so the type fo treatment you would need or even additons you would have to make tot he neupogen can not be ascertained. Im assuming of you are using neupogen that other immune testing has been done?
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

clairl

3 Posts
Reply RE: HLA testing and neupogen treatment Posted on: Dec 10, 2013 at 4:04pm
Yes we've had all level 1and 2 immune tests done via Chicago lab. All came back normal
except mthfr c677t gene mutation. No killer cells in uterine lining either. My husband and I are no match on the DQ alpha test. These tests were done however pre any of my 4 ivf/ Icsi
Then very recently my husband tested positive for chlamydia and ureaplasma. I've tested negative for any of these infections.

Neupogen has been suggested to treat 3 missing KIR. LIT has been suggested for low LAD but I've never been pregnant beyond 6.5 wks nearly a year ago.

It seems we've done most tests except HLA matching? Is is this necessary given all other tests are normal?

Clair
clair lewoski

Dr. Braverman

2026 Posts
RE: HLA testing and neupogen treatment Posted on: Dec 10, 2013 at 5:48pm
I dont know what Level 1 or Level 2 denotes. There is only One set of complete immune testing that should be done I suspect you have not had this yet.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.