Homo and hetro MTHFR


2 Posts
Reply Posted on: Aug 7, 2012 at 4:15am
I have been diagnosed with hetro c677t and homoA128c. I have had 5 miscarriages all ending prior to 6-9 weeks. I am 42 yrs old and have a amh of 31. I have a tsh of 2.6 all other immune issues appear to be normal. Could you advise if you believe high dose fish oil would have the same effect as clexane? Do you think the MTHFR is causing an issue?

Dr. Braverman

2026 Posts
RE: Homo and hetro MTHFR Posted on: Aug 7, 2012 at 6:34am
No I dont think its the MTHFR you would need folic acid and B supplements for that.
I think you need a more complete workup to determine the cause of all your losses. Im not sure you have it right as you can only have 2 MTFHR genes if both are A12C then you are homo but if you have one of each you are hetero for each. But you cant be hetero for one and homo for another that would require 3 genes and you only have 2.

I would be happy to guide you if you wish, you can call for a free brief interview so we can discuss.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.


2 Posts
Reply RE: Homo and hetro MTHFR Posted on: Aug 7, 2012 at 9:34pm
Thanks Dr Braverman,

That would be great to have a brief discussion, I have emailed you directly with some details.

Look forward to hearing from you.