How much progesterone do I need?

Lisey

1 Posts
Reply Posted on: May 3, 2014 at 3:42am
Hello there, I'm 34 and coming up 12 weeks pregnant with my 19th pregnancy. We have no children. I always miscarry due to immune issues and implantation failure. I have never been this successful and always lose at around 6-8 weeks. Everything seems to be well controlled this time, but I have concerns about reducing the amount of progesterone I am taking and how it might affect the pregnancy.
My serum progesterone levels are good and always have been. But I have been on progesterone pessaries (cyclogest) 3 times a day and progesterone injections (gestone) daily for it's immune effects and as a safeguard against deficiency. Despite this and my serum levels being excellent with this regime, the corpus luteum disappeared before 8 weeks.
The foetus is very healthy, developing well and there are no apparent problems.
The plan is to stop the progesterone injections at the end of the 12th week,
continue with 3 progesterone pessaries until the end of the 16th week and reduce to 2 pessaries for the reminder of the pregnancy.
I wonder if you think this is a wise plan or whether you would suggest any alterations to this?
I am also having intralipid infusions regularly and am on clexane 20mg twice a day to keep my immune system calm and prevent various complications occuring. Prior to pregnancy my Chicago immune panel levels were all normal, but obviously there are concerns given my miscarriage history and my immune issues, which are Behcet's Disease and Category 2 and 5 immune issues as defined by Dr. Beer.
Many thanks in advance for your response. I would greatly appreciate any advice you could give me.
L Laraman

Dr. Braverman

2026 Posts
RE: How much progesterone do I need? Posted on: May 3, 2014 at 6:39am
I am very happy for you that you have made it this far. I dont think the progesterone is the key issue here. With immune issues there are issues that need to be addressed even once you are at 12 weeks especially with your history and the Bechets. I would be happt to discuss this case with you , fill out a consult form on the website and we will arrange a free 10 minute chat or you can just email me (email addresss on the website , with your phone number and I will call you).
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.