Insulin Resistance?

sunshineplease

Reply Posted on: May 3, 2012 at 10:48am

Dr Braverman,

I was recently tested for Insulin Resistance. This was based on my FSH (10.1) and LH (15). My results for the IR were as follows:

Glucose Tolerance Test
Fasting: 84 mg/dL
1 hour: 97 mg/dL
2 hour: 75 mg/dL

Insulin Response to Glucose
Fasting: 5 uIU/mL
1 hour: 27 uIU/mL
2 hour: 23 uIU/mL

Based on these results, my RE said I need to start Metformin before IVF in June. I am unsure how to interpret this--are these results abnormal? Please assist and let me know what you think.

Thanks.

Dr. Braverman

2026 Posts

RE: Insulin Resistance? Posted on: May 3, 2012 at 11:08am

there is no perfect way to screen for insulin resistance, they did the appropriate tess and they are borderline at best. I base the need for metformin on many issues including previous response to IVF , clinical symptoms, and of course your LH/FSH ratio. In general I have found the time to start metformin is when you are "thinking" about starting metformin. Remmber I always also look at your previous IVF or pregnancy loss history to help in this determination.

Braverman Medical Team
Braverman Reproductive Immunology P.C.

sunshineplease

2 Posts

Reply RE: Insulin Resistance? Posted on: May 3, 2012 at 4:17pm

I have never done IVF. I am considering it for family balancing purposes and fertility preservation.

I have no clinical symptoms consistent with PCOS, no miscarriage history.
My RE (different state) was basing the recommendation for Metformin based on the aformentioned IR results and my day 3 FSH (10.1) and LH (15).

I am just confused because my local RE said I am NOT IR/PCOS and I don't know what is accurate?

Dr. Braverman

2026 Posts

RE: Insulin Resistance? Posted on: May 4, 2012 at 8:05am

Its becasue your levels are borderline that you are getting different opinions. In this case because there are no clinical findings or history , I might agree to hold off on the metformin and only start it should the outcome of an IVF cycle not be optimal.

Braverman Medical Team
Braverman Reproductive Immunology P.C.

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