Interpretation of HLA matches

Hope4baby22

2 Posts
Reply Posted on: Jan 20, 2015 at 1:48pm
Dear Dr.Braverman,

Below are our HLA results and my NK activity (E:T 50:1 Native State 8.7)
DQ Alpha Me:0103(1.3),0302(3.1) Husband:0103(1.3),0104(NA)DQ Beta Me:03,06 Husband:05,06HLA-A Me:02,26 Husband:02,11HLA-B Me:40,52 Husband:07,18HLA-C Me:03,12 Husband:07,17HLA-DRB1 Me:09,15 DRB4,DRB5 Present DRB3 ABSENT

Husband:14,15 DRB3,DRB5 present DRB4 ABSCENT

Thanks for you valuable time to answer my questions.

1.Are DQ alpha 0103,0104 are similar or different ?
2.I have many HLA matches.Please suggest whether I need to use neuopogen or will it be fine to go ahead with prednisone and Intralipids?
3.Do you think these matches will be insignificant as I do not have elevated natural killer cells?

Dr. Braverman

2026 Posts
RE: Interpretation of HLA matches Posted on: Jan 20, 2015 at 2:03pm
We would need to perfrom a full consult on you to go over these labs in detail , I can answer fairly general quesitons but to recommend therapies requires that we go over all immune data that we send. It is a much more comlicated issue than what you are looking at. Feel free to fill out a consultation request and I will be happy to schedule a free 10 min consult with you.
DQalpha 0103 and 0104 may be simialr enough that they do not generate antigenic differnces. But this does not appear to be an HLA issue with you and your husband.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Hope4baby22

2 Posts
Reply RE: Interpretation of HLA matches Posted on: Jan 21, 2015 at 11:04am
Thank you Doctor for your kind reply.So does it means I have partial DQ alpha match with my husband ?I will schedule a appointment with you.

Dr. Braverman

2026 Posts
RE: Interpretation of HLA matches Posted on: Jan 21, 2015 at 11:51am
no such thing as a "partial DQalpha match" so forget you ever heard that :). Look forward to speaking with you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.