Intra Uterine Treatments making exciting breakthroughs

Dr. Braverman

2026 Posts
Reply Posted on: Jan 4, 2012 at 8:00pm
Many new treatments for recurrent pregnancy loss and failed IVF are being directed to the intra uterine environment. The concept is to try and control the immune cells directly at the site of embryo implantation. Three of these new therapies are

1. Infusion of HCG into the cavity
2. Infusion of a patients own White blood cells into the cavity(some treated with HCG prior to infusion)
3. Infusion of neupogen (G-CSF)

All of these have the same theory in thier action- to modify messenger dendritic cells and macrophages to their tolerant or immature state and assist the immune system in the production of T regulator cells, which limit the immune attact against the embryo and enhances implantation.
There is also evidence they assist in the conversion of stromal uterine cells to those of pregnancy called decidiual cells and this conversion is critical for embryo implantation.

We have had great success using the neupogen flush and will begin offering these other therapies shortly.
Braverman Medical Team
Braverman Reproductive Immunology P.C.

Pthgrl

1 Posts
RE: Intra Uterine Treatments making exciting breakthroughs Posted on: May 30, 2012 at 8:00pm
I would be very interested in hearing about your experience with g-csf. How many patients have you treated? What was your success rate?

While there have been many (perhaps well-deserved) hoopla in the media about the original article by Geischler, there does not appear to be any other articles on this subject by others.

Any additional info would be greatly appreciated.

Thank you in advance.

Dr. Braverman

2026 Posts
Reply RE: Intra Uterine Treatments making exciting breakthroughs Posted on: Jun 6, 2012 at 11:08am
We have also had very good success with the intrauterine G-CSF. You are correct there are no new studies out, but I feel it is a safe and effective method to help with uterine lining issues. and have had good results in our practice.
Braverman Medical Team
Braverman Reproductive Immunology P.C.