Intralipids in the second trimester

Marie72

3 Posts
Reply Posted on: Aug 11, 2014 at 10:38pm
I am currently 12 weeks pregnant and was tested with my husband to have 8 hla matches. I have been on lovenox since 6 weeks but no intralipids up until now. My lost loss was at almost 16 weeks no cause found,normal chromosomes etc. i have had five miscarriages, 4 late trimester losses and one second. Would it bennifit me at all to do intralipids at this point or is it too late for that now? Thanks for your help.

Dr. Braverman

2026 Posts
RE: Intralipids in the second trimester Posted on: Aug 12, 2014 at 6:09am
Of course I cant comment on what you would need wihtout having all of the necessary testing performed to diagnose second trimester losses, which many times is completely different thatn the mechanism behind first trimester. I would need to know not how many matches you have but how many mismatches between you and your husband especially on the class 2 HLA alleles. Are there any HLA antibodies?
You would need to know this prior to deciding on the correct therapy for the second trimester.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Marie72

3 Posts
Reply RE: Intralipids in the second trimester Posted on: Aug 13, 2014 at 2:37am
Yes, i tested positive on hla antibodies
matches on hla are as follows

Myself Husband
dq alpha 0201 (2) 0301 (3.1). 201,0301

dq beta 02,03. 03,03
Hla-a 01,23. 01,01
Hla-b 07,44. 08,15
hla-c 07,44. 01,07
hla-drb1 04,07,drb4 present. 04,07, drb4 present

i did the testing with you and was a patient for 6 months but had failed iui's and ivf (not done with your clinic) this pregnancy was natural and surprise 3 years later

your therapy with me at the time being a patient was to be nuepogen,intralipids and lovenox through prior to conception through twelve weeks. I was not able to do that this far in this pregnancy this time and have only been on lovenox from 6 weeks on. Becuase I have not been on intralipds or nuepogen I am wondering if at this time this late into it if the intralipids might help slightly or if that window has closed

At the time of testing (not pregnant) these were my abnormal results
tnf a il10 high
cd19/5 low
kn assay .5:1 10-40 result 22.9
the red cross sent me a letter saying I tested positive for hla antiboies

Marie72

3 Posts
Reply RE: Intralipids in the second trimester Posted on: Aug 13, 2014 at 2:46am
I forgot to mention I developed Graves after my ivf/iui cycles but am currently in remission and so far thyroid labs have come back normal each month

Dr. Braverman

2026 Posts
RE: Intralipids in the second trimester Posted on: Aug 13, 2014 at 6:21am
Ok you need to call me and I have to go over all of your old records , this can not be done over this forum.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.