Is there a max IM progesterone that can be used?

froggie

3 Posts
Reply Posted on: Nov 21, 2012 at 5:57am
I have been on 100ml of IM progesterone as prep then luteal phase support for a DFET. On the day of the transfer, after 3 nights of these shots, my serum P4 was only 0.1 nmol/l. Obviously we are going to increase the shots! But I was wondering is there a maximum amount one could inject each day? I can't find any literature on this anywhere, just folks saying that prog. supplementation not really necessary but can't hurt, etc etc.

I've also tried progesterone suppositories for FETs & after fresh transfers & always have problems keeping my levels up after ETs -- but they are fine during IVF stims with Gonal. So it must be problems assimilating the meds?

Thanks for this awesome forum, hope you guys survived the Superstorm all right.

Dr. Braverman

2026 Posts
RE: Is there a max IM progesterone that can be used? Posted on: Nov 21, 2012 at 6:23am
You should simply change to vaginal admistration. Obviously the IM route is not working. The vaginal route is not supposed to raise serum levels so you can not use that as a guide , but is almost always effective . Endometrin or Crinone would suffice. Again I dont know your case so in the end you must follow the advice of your doctor.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Dr. Braverman

2026 Posts
RE: Is there a max IM progesterone that can be used? Posted on: Nov 21, 2012 at 6:23am
You should simply change to vaginal admistration. Obviously the IM route is not working. The vaginal route is not supposed to raise serum levels so you can not use that as a guide , but is almost always effective . Endometrin or Crinone would suffice. Again I dont know your case so in the end you must follow the advice of your doctor.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

froggie

3 Posts
Reply why doesn't serum P4 reflect progesterone suppository use? Posted on: Nov 21, 2012 at 6:32am
OK, thanks.

Is there a max amount of suppositories that can/should ever be used?

Why don't progesterone suppositories show up as serum P4? People always say that & I find it confusing -- since presumably the hormone enters your blood stream somehow??

Dr. Braverman

2026 Posts
RE: Is there a max IM progesterone that can be used? Posted on: Nov 21, 2012 at 7:20am
most gets absorbed lcoally into the uterine cavity , significantly less into the vascular system, this is well know on my crinone patients I rarely see progesterone levels over 10.

I would use one crinone or 2 enometrin on fresh IVF or IUI and 2 crinone and 3 endometrin on FET .
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

froggie

3 Posts
Reply RE: Is there a max IM progesterone that can be used? Posted on: Nov 21, 2012 at 7:30am
Gotcha, thanks.

Still waiting for answer from my doc, & I've already got 2 answers from you, great job!!

Dr. Braverman

2026 Posts
RE: Is there a max IM progesterone that can be used? Posted on: Nov 21, 2012 at 8:11am
ok thx, make it 3 now!
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.