MTHFR and infertility


1 Posts
Reply Posted on: Oct 4, 2013 at 9:55pm
I just found out that I am homozygous for the C677T mutation. My labs were all normal and yet we ultimately needed IVF to get pregnant. I was told I had poor egg quality after that IVF cycle yielded 1 2AA embryo out of 14 eggs retrieved (only 4 of 9 mature eggs had fertilized). She's now 15 months old. It was my one and only pregnancy and I was on extra folic acid and baby aspirin (stopped it at the end of the first trimester as per my RE clinic protocol). Didn't have any issues with the pregnancy. I haven't had any clotting disorder testing done but the test for MTHFR was through genetic testing with 23andme and it said I wasn't a carrier for Factor V Leiden at least. We're now TTC #2. Undergoing testing since we assume IVF will be needed again. AFC much better as well as AMH compared to IVF #1 numbers but other labs still nice and normal. So if I didn't need lovenox last time, would I need it this time? I'm back on the baby aspirin at least. I'm doing IUI this cycle but if it's a bust, have to take a cycle off for a hysteroscopy to check out what looked like a polyp or some sort of debris that was seen on an SIS I had done earlier this week. Have to do that before proceeding with IVF in January per my doc's recommendation.

Dr. Braverman

2026 Posts
RE: MTHFR and infertility Posted on: Oct 5, 2013 at 6:14am
I could never give advice about what you would need without knowing your entire case and seeing all the testing I would use to make these types of decisions . C677 does beneift by lovenox, if you did not have a problem with your first pregnancy it makes it more unlikely that you would need it and baby asa and folic acid may suffice. I dont like the SIS for that reason and always go right to a simple video hysteroscopy in the office so there are no questions.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.