Neupogen Uterine Wash - can it cause bleeding?

miracleseeker

2 Posts
Reply Posted on: Jan 24, 2013 at 9:03am
Hello there,
We have had 7 failed IVFs... one of which was a surrogacy cycle and one donor egg one - all 5 cycles with immunes (full humira, IVIG, Steroids and clexane and LIT).

This is my last IUI (thought it would be easier than IVF). I had a Neupogen Uterine wash 2 days before my IUI. On day of IUI I had bleeidng from my cervix.

I am concerned that the Neupogen caused this. Also Ive been told to inject 15mu Neupogen subcutaneously every other days 2 days after IUI.

Ive never tried this medication. Ive done 1 Intralipid drip and am on 25 Prednisolone and 60mg clexane for MTHFR Homozygous (as well as 5mf folic acid).

This is all emperical tx as in the past we have had TNF levels of 61 or so... (2 yrs ago). I wanted to keep it simple.. this time and know I didnt want to do IVIG or Humira or LIT.

We also have DQ Alpha match of dh 0102,0102 me 0102,0505... LIT has never helped me...

Do you think I should be weary of doing the Neupogen? I am scared of doing myself damage...

Thanks

Dr. Braverman

2026 Posts
RE: Neupogen Uterine Wash - can it cause bleeding? Posted on: Jan 24, 2013 at 9:18am
I dont think the neupogen wash was an issue, however based on your history I dont think that it is the problem. Your workup also seems incomplete and their may still be other options. At a minimum you need the complete HLA profile as their is no significance to a DQalpha match by itsef. I would be happy to guide you , feel free to call my ofice and they can schedule a consultatoin for you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

miracleseeker

2 Posts
Reply RE: Neupogen Uterine Wash - can it cause bleeding? Posted on: Jan 24, 2013 at 10:18am
Hello
I have always wondered about the further DQ Alpha or Betas - is this what you mean about further HLA testing... It could be an egg issue but I have been pg twice naturally (once blighted ovum and second the pg stopped developing at 6 weeks no heartbeat). Then again I started ttc in my 20s so it can't be eggs can it?

Ive had mild endo, arcuate uterus ... and do get flue like symptoms just before test day.

I also have pcos and am on Metformin 500mgx3 a day.

Can you advise on how much your consultations cost.

I must admit part of me tells me after so many years that if this does not work to do another surrogacy cycle but this time with testing on our embryos. And if that does not work then amybe DE and surrogacy...

Dr. Braverman

2026 Posts
RE: Neupogen Uterine Wash - can it cause bleeding? Posted on: Jan 24, 2013 at 10:28am
ok we should speak at least I can better direct you on which path to take. You can call my office and they will scheudle this.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.