NK cells and TH1:TH2 ratio


21 Posts
Reply Posted on: Sep 24, 2014 at 4:30am
I am in Australia, but I have just had blood test results back saying my TH1;Th2 ratio is normal, I have a slightly higher IL 10 (9pg/ml) but otherwise all other cytokines normal (INFg,IL1,IL2, TNFb, IL4,IL5,IL6, IL10, IL13, TNFa, TGFb).
My TNFalpha is 0.39pg/ml.

I have been diagnosed with high NK cells (more than 30 per high power field in my uterus). My question is - If I have such high NK cells, wouldn't INF gamma be raised and wouldn't I show a TH1 bias.

I have had 3 very early miscarriages. I have only history of eczema and all other autoimmune tests came back negative and I don't have a strong family history of AI disease. Can some people have high NK cells, but they aren't very active?? I wonder if my miscarriages could be caused by my husband and I both being homozygous MTHFR and we weren't on the methylfolate supplements when the 3 miscarriages happened... or am I clutching at straws here. We don't have any HLA matches either. I can't find any other reason except for NK cells. Any suggestions?

Dr. Braverman

2026 Posts
RE: NK cells and TH1:TH2 ratio Posted on: Sep 24, 2014 at 1:04pm
My suggestion is to get a complete immune workup by someone that understand immunology , and you should not have to do any of this research by your self. Your conclusions are based on minimal kowledge and information in a field that is quite complex. Some have tried to make testing and diagnosis simplified but unfortunately if done correctly it is not.
My advise is to call our office or submit a consult request and we can set up a free 10 minute chat to reveiw your case.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.