Reading DQA/HLA matches...

Texas13

4 Posts
Reply Posted on: Jan 23, 2013 at 10:41pm
Hi Dr. Braverman,
We talked a couple months ago about my failed donor egg/embryo transfers (no implantation). You suggested I get further immune testing and I've been working on that with my RE and Reprosource labs so I can get more info before proceeding with future plans for our 2 frozen embryos (I've never been pregnant and just now at age 45 have received 2 embryos with donor eggs and DH's sperm on separate transfers). I just got back these results on the DQA/HLA tests and I'm wondering how this is interpreted as far as number of matches and significance. I think my husband's results are very interesting that they are all paired up. Is that rare? Doesn't this mean his parents were a complete match for him on all of these? How did he get here? Lol. How bad are our numbers?For me:DQ Alpha: 0102 (1.2), 0501 (4.1)DQ Beta: 02,06HLA-A: 11,25HLA-B: 08,27HLA-C: 02,07HLA-DRB1: 15,03/13 DRB3, DRB5 presentFor him:DQ Alpha: 0102 (1.2), 0102 (1.2)DQ Beta: 06,06HLA-A: 03,03HLA-B: 07,07HLA-C: 07,07HLA-DRB1: 15,15,DRB5 present

Thanks. Also, have you figured out a way to co-treat/work with a patient's local RE? I know you were working on this when we last messaged.

Dr. Braverman

2026 Posts
RE: Reading DQA/HLA matches... Posted on: Jan 24, 2013 at 6:36am
There are clearly matching issues here as well as you having a combination of HLA genes that is related to abnormal production of HLA G a very important molecule for helping to create immune tolerance for the embryo. As it is most likely that this toleracne is created when the sperm come in contact with your immune system, changing the egg here does not usually prove successful.
Why dont you email me at [email][email protected][/email] and we can discuss how and if we can coordinate treatment for you .
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.