Recurrent chemical pregnancies with CGH blasts

Leslieco12

6 Posts
Reply Posted on: Jul 23, 2013 at 11:52am
I've had two chemical pregnancies in a row from natural FETs of CGH tested blasts. First FET was 2 blasts graded A and B. Second FET was one blast graded C. Both time the betas got over 100 then stopped doubling. I also had a chemical pregnancy back in August 2012 with a frozen blast from a retrieval in 2010. That time the beta never got above 11.I had iimmune testing last month and the only thing that came back abnormal was NK activation at 29%. I also discovered that I am homozygous for MTHFR C677T (but with normal homocysteine levels). This past cycle I was on Lovenox and Prednisone and baby aspirin. I should add that I have one 2.5 year old child conceived via IVF. At that time my NK activation was 17% but nothing was done to treat it (RE did not believe in it). I wasn't on anything for MTHFR because I didn't know about it yet. Do you have any thoughts for how I should proceed?Just FYI, these are the tests I've had and everything has come back normalCA125
Factor V
Antithrombin activity
Homocysteine levels
Protein C
Protein S
Prothrombin 2021A
DQ AlphaI also just did HSG and both tubes were open and there was no hydrosalpinx.I've had two other chemical pregnancies and an ectopic in the past (treated w methotrexate), and I also had 3 surgeries to remove a uterine septum about 6 years ago.Lastly, I tested positive for thyroid antibodies in 2009. I was on synthroid at the time for slightly elevated TSH but am no longer on medication and my TSH is normal. Also in 2009 was tested for APAs (negative) and DRVTT (negative).

Dr. Braverman

2026 Posts
RE: Recurrent chemical pregnancies with CGH blasts Posted on: Jul 23, 2013 at 2:49pm
Your testing is insufficient for me to make a recomendation . Please ready my blog on HLA testing it might help to explain a little for you . Best would be to fill out a consult request on my webste and we can have a brief 10 min chat to go over your case and the need for our services. I will complete the immune workup that you clearly need. NK cells alone do not give you any valid information on treatment.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Leslieco12

6 Posts
Reply RE: Recurrent chemical pregnancies with CGH blasts Posted on: Jul 23, 2013 at 3:03pm
Is that the same as DQ Alpha? I did that. I am 2.0, 4.1 and my husband is 1.2, 1.2

Dr. Braverman

2026 Posts
RE: Recurrent chemical pregnancies with CGH blasts Posted on: Jul 23, 2013 at 3:09pm
Please read my blog on HLA it will explain , DQalpha alone is inadequate.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Leslieco12

6 Posts
Reply RE: Recurrent chemical pregnancies with CGH blasts Posted on: Jul 23, 2013 at 3:32pm
Thank you -- I filled out a consult request. I suspect I need more than just the HLA test... Looking forward to speaking with you.