Recurrent Double Donor Embryo Implantation Failure

Tina Y

1 Posts
Reply Posted on: Sep 25, 2013 at 11:58am
I am 44 years old. Previously had one natural pregnancy ending in m/m at 10 weeks. History of mild endometriosis and ovarian cysts (but not PCOS). Taking Levothyroxine for underactive thyroid, TSH has been in normal range for 2 years.

After 3 failed IVF/ICSIs I had immune testing which showed slightly elevated NK cells, DQ alpha match, PAI-1 hetero and MTHFR hetero.
Went onto double donor embryo cycles with young proven donors, different donors each cycle.

The first donor cycle (clexane, steroids, aspirin, intralipids, progesterone) was negative.

I then had a hysteroscopy, no abnormalities found and implantation cuts made. I had antibiotics as I tested positive for Hidden C, ureaplasma and mycoplasma.

Second donor cycle was positive (excellent lining, lots of antibiotics, anti virals, clexane, aspirin, steroids, PiO, intralipids). The yolk and sac developed but the embryo did not develop. D&C.

Third donor cycle (excellent natural lining, clexane, aspirin, steroids, intralipids, PiO, Neupogen) was negative.

In your experience, what might be the most likely reason for donor embryo failures?

What could cause an embryo to implant but not develop?

I have no funds left for tests or treatment but I am curious to know if you have an opinion as it has baffled both myself and my consultant.

Kind Regards

Tina Y

Dr. Braverman

2026 Posts
RE: Recurrent Double Donor Embryo Implantation Failure Posted on: Sep 26, 2013 at 6:35am
of course without a complete workup in my lab I cant say , but it might be that you had the right treatments but not the right doses, the only way to know any of this is to follow the immune parameters during your treatment so you can make modifications.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.