Recurrent miscarriage immune issues or egg quality


1 Posts
Reply Posted on: Feb 3, 2015 at 1:16pm
Dear Dr Braverman,

I would be very grateful of your help. From 2011 to 2014 I have had 4 recurrent miscarriages. The last one was a partial molar pregnancy however my hcg levels dropped quiet fast and I didn't need further treatment after surgery. I haven't had problems with getting pregnant but sustaining the pregnancies has been the issue. For all pregnancies a foetal hearbeat was detected before the miscarriages. The first miscarriage occurred at 7 weeks, the 2nd was a missed miscarriage where I thought I was in my 13th week but was told the heartbeat had stopped at 7 weeks, the 3rd occurred at 9 weeks and was again a missed miscarriage and with the last I found out at the 8th week scan that it had again stopped around 7 weeks. For the third pregnancy I was taking heparin injections but had only started these about 3 days before the miscarriage occurred. With the last pregnancy from a positive pregnancy test the treatment protocol was 25mg daily prednisolone for 4 weeks then reduce by 5mg every 3rd day for 3 weeks until 14 weeks, cyclogest 400mg twice a day for 12 weeks, gestone 50 mg daily, heparin 3500 iu every day. I have been diagnosed with iga nepropathy whereby I am taking 200mg twice daily labetalol (Trandate) for hypertension, however the consultant that I attend did not think it to be associated with the miscarriages and I have had no other major health problems with it. I have an underactive thyroid and take 25mg once a day. There were questions about whether I had some markers for SLE and blood results showed a weak positive test for ANA. I have had lots of immunological tests done including the NK testing but nothing else showed up apart from the ANA tests.
I have seen various specialists in Ireland and have had varying answers to the reasons for the miscarriages. The last specialist that I attended before the partial molar pregnancy occurred said she thought there were some auto-immune issues and I should have been on the meds before ever becoming pregnant and that IVF probably wouldn't work due to it being an immunological problem. However I have since moved to the UK where I saw another specialist last week however she barely glanced at my test results or history and was dismissive of any immune issues and I was told that IVF and donor eggs was possibly the only way to go. Apologies for the long message but I'm writing in some hope that you can point me in the right direction or is there any hope? My amh levels are normal for my age but perhaps it is just a case of poor egg quality? My partner has had all the relevant tests also and no issues were detected. I am now 43, we do not have any other children, I'm terrified to go through another miscarriage but find it difficult to think I will never have a child.

Mrs Powers

2 Posts
RE: Recurrent miscarriage immune issues or egg quality Posted on: Feb 4, 2015 at 1:40pm
Hi there, I'm really sorry you are going through all of this. I empathise completely and am in a similar position. I'm also from Ireland and am considering the testing with Dr. Braverman as I can't face another. Miscarriage. If you want to get in touch Lmk.