Repeated failure

Lauren A

1 Posts
Reply Posted on: Apr 4, 2015 at 11:17am
Dear Dr Braverman,

I am seeking your advice as am unsure of what to do next...and am overseas.
I am now in later 40's. I tried 19 ivf cycles using own eggs. During this time, I had 2 chemical pregnancies. I also have Hashimoto's and positive for thyroid antibodies. At that time, a hysterectoscopy revealed uterine NK cells.

We then moved on to use donor eggs. Using IL, Dexamethasone, Clexane and aspirin I had a successful pregnancy. One child born even though 2 day 5 embryos transferred.

Since then, I've had 3 unsuccessful transfers using the same protocol outlined above. The first was 2 day 5 were embryos transferred (genetically untested). The second transfer was one genetically normal and the last was another normal embryo. I also had IVIG plus all the other medications already mentioned for the last failed cycle.

As I was at a loss as to why it's so difficult the second time using donor embryos, my specialist tested my husband and I for dq alpha genes. We have a 101and 103 match.
My specialist is now suggesting LIT but my physician who will be performing the transfer does not believe in immune treatmentat all and suggesting surrogacy, which after all these years, we can't afford.

I'm just so confused. Why was it so easy the first time with the donor and now so difficult.......I would be very grateful for your advice.

Thank you

Dr. Braverman

2026 Posts
RE: Repeated failure Posted on: Apr 5, 2015 at 8:11am
Based on your history I am very suspicious for endometriosis , which can affect both your embryo quality and behaviour. Endometriosis can also lead to failed implantation of a normal embryo which is why you may have filed the donor embryos. I see many cases such as this and many times we can treat and go back to using your own eggs.
(please see the endometriosis portion of our website to understand) .
Best would be to schedule a free 10 minute consultation by phone or SKYPE and we can discuss your case in detail.
Simply fill out an online consultatoin request and we will be in touch with you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.