repeated second trimester loss...trying to find reasons

unakm

2 Posts
Reply Posted on: Jan 5, 2013 at 12:25pm
I am 34, DH 38. I had FOUR losses in last three years. No living children.

First pregnancy - 13 weeks - limb body wall defect - CVS Normal Chromosoms - pregnancy terminated. Baby was measuring 1 week behind from the beginning.

Second pregnancy - 15 weeks pPROM - NT Scan perfect - baby was healty - pregnancy terminated for risk of infection to baby and me. Still I regret that decision.

Third pregnancy - 8 weeks early miscarriage

My OBGYN did hystroscopy after these three losses. She found septum in the uterus, two large fibroids, and two thick scar tissues.

She did second sergical hystroscopy to remove septum, fobroids, and scar tissues.

Fourth pregnancy - 20 weeks preterm labor and still birth. Baby was measuring two weeks behind since 9 weeks. First trimester screening very low PAPP. T13-21 risk 1 in 5. At 16 weeks subchronic hematoma. 19 weeks 5 days amnio done. I had preterm labor and baby born still. Amnio came normal.

Baby No.4 had cleft palate, hole in the heart, fused kidneys, fused trechia.

After my fourth loss, I am completely devasted. I don't want to write anything for emotional state.

Anyway, I had MTFHR test done after my second loss. Everything came normal except folic acid cerculation deficiency.

My doctor did third hystroscopy after my fourth loss- uterus biopsy. Normal reports.

After my fourth loss, doctor did blood test for me and DH - chromosom reports normal.

I have irregual period frequency 45 days, 35 days, and 32 days.

Baby 1 and 4 concieved after 45 days period. Both babies had normal chromosome but had fetal birth defects. Baby No.2 was healthy but we lost it because of my uterine septum.

My current OB says, I don't have any issues in my uterus. It is corrected.

I am afraid of birth defects. But I also think I have some harmone problem which are created problem in fetus development.

In our family history everone is pretty healthy, having kids, no health concerns.

Please help me. What do you think what could causing all these losses? Is there anything we can prevent these conditions? I have a great doubt that there is some problem in my uterus or harmone problem.

My doctor did hystroscopy. She said everything OK. But I think, I need HSG or SHG to determine residue of septum and scarring in my uterus.

Can you please help me what can I do next?

Thanks in advance. Looking for hope and guadance.
unakm

Dr. Braverman

2026 Posts
RE: repeated second trimester loss...trying to find reasons Posted on: Jan 5, 2013 at 9:24pm
I am sure I can help you understand why this is happening. You really need to come and see me here in NYC or at least if you are a distance away schedule a SKYPE consult. It does appear that there are two issues here , one is some problem with the uterine cavity that I would really have to look at all the records of your surgeries and any other sonograms you have had. Then we need to see what if any immune issues may be present as a chronic long standing attack against the placenta can also lead to these issues. Please call me so we can start to figure this out for you. I am very sorry for these terrible losses.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

unakm

2 Posts
Reply RE: repeated second trimester loss...trying to find reasons Posted on: Jan 5, 2013 at 9:47pm
Dr Braverman,

Thanks for your quick reply. Yes I am going to call you for appointment scheduling. I would prefer Skype appointment. I am in Missouri.

I missed few things - my blood group is b negative. I had several rhogam shots. My DH blood group is AB+.
In my last pregnancy, placenta was a mega placenta, larger than usual.

I have too many concerns. I really need guidance.

Thanks.
unakm

Dr. Braverman

2026 Posts
RE: repeated second trimester loss...trying to find reasons Posted on: Jan 5, 2013 at 9:54pm
Ok i will help you , we can not do SKYPE, all consults unfortunately must be in person as per state medical guidelines.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.