Sperm Chromosome Abnormalities

luvmyboys

5 Posts
Reply Posted on: May 19, 2014 at 6:27am
Dr. Braverman,

We cycled last year (age 30, spouse was 32) for family balancing. We have 2 boys (age 3 and 9) who were conceived naturally. During our cyle, we had 14 eggs retrieved, 11 mature, and 11 fertilized. They were able to biopsy 8 on Day 5. We were devastated to learn that only 2 embryos had normal chromosomes (we expected at least 4 with our ages). Luckily, we had used Natera (GSN) for the 24 chromosome screening, so we were able to see which side the abnormalities came from.

It turns out that 5 out of the 8 were completely normal on the egg side. This was completely in line with what we expected. However, 6 out of the 8 embryos had abnormalities on the sperm side. 3 of the 6 had multiple chromosome issues. The remaining 3 had issues only with chromosome 13 and 14. We were told by Natera that they suspected a Robertsonian Translocation. We were shocked because how would we have conceived in the past with no miscarriage in sight? We completed a karyotype (blood) for him and all came back normal. Because of this, Natera said he either just had really bad luck or that he might have gonadal mosaicism?

I am concerned that we will keep having issues if we continue to cycle? Do you think the results were a fluke? Or, is it possible for a normally fertile man to find out that he has gonadal mosaicism? Is there anything else that can cause this? We have never had problems conceiving and have never had a miscarriage before. I just think if he had a real issue that there would have been a sign at some point...I do realize that most chromosome issues come from the egg, so we were a bit shocked.

At the time of the cycle, he was binge drinking (8+ beers a day), drinking 2-3 energy drinks, etc. Could these lifestyle factors have caused the issues? He has since given up alcohol and energy drinks in hopes that this will improve his sample. He has also started Zinc, Folic Acid, Cyvita, and Vitamin C in hopes this helps as well.

My biggest fear is that someone says we need donor sperm or that this will not work for us when it should. My husband is completely against donor sperm. Please tell me what you think. Thanks so much for your help!

Dr. Braverman

2026 Posts
RE: Sperm Chromosome Abnormalities Posted on: May 19, 2014 at 6:45am
I agree with you that with 2 normal children you should be able to have another. When I have had cases like this I have done the family balancing and only tested for gender with great success, the embryos have a way to "auto" correct these defects and you may be eliminatiing normal embryos.
I would be happy to assist you with this .
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

luvmyboys

5 Posts
Reply RE: Sperm Chromosome Abnormalities Posted on: May 19, 2014 at 12:56pm
Can these still auto-correct if they were Day 5 biopsies? I knew this could happen with Day 3, but can they with Day 5?

He had 3 embryos that were normal on my side that showed a missing or extra chromosome 13 or 14. These were both Expanded Blasts on Day 5. So, you think these might have been normal?

We had a bad gender split (4 boys and 1 girl) so I only had 1 transfer.

Are there any sort of genetic issues that he could have if he has a normal karyotype and has fathered 2 children? Could this be from DNA fragmentation?

Dr. Braverman

2026 Posts
RE: Sperm Chromosome Abnormalities Posted on: May 19, 2014 at 12:59pm
the biopsy of the outside of the blast is from cells that were discarded from the inner cell mass, it is not a direct analysis of the inner cell mass which makes up the baby. Studies have shown that these are still not completely reliable. I would do no futher testing and just make good embryos and place them in.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

luvmyboys

5 Posts
Reply RE: Sperm Chromosome Abnormalities Posted on: May 19, 2014 at 1:07pm
Thank you!

We were seriously freaking out thinking he had something wrong with him! So, you don't think he could have some sort of underlying condition that we weren't aware of? I mean, we would have a history of miscarriages or something if he had chromosome issues, right?

Dr. Braverman

2026 Posts
RE: Sperm Chromosome Abnormalities Posted on: May 19, 2014 at 1:09pm
correct, I would be happy to help you with your next cycle. I do many gender seleciton cases and am the consultant for Gender Dreaming.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.