Th1 or Th2 Dominant?


3 Posts
Reply Posted on: Sep 18, 2013 at 11:24am
Hi Dr. Braverman,

I"m wondering how you know for certain if you are Th1 or Th2 dominant. I know hashimoto's is usually a TH1 dominant disorder, but also know it's not always as easy as that.

So....I've had my TNF/IFN cytokine ratios done and my TNF-a:IL-10 is high at 33 and my IFN-g:IL-10 is apparently normal at 16.

My CD%56 cells (I think those are NK's) are at 9.2, but my %CD19 is high at 17.1.

I've researched and researched and am trying to figure this out--if my TNF-a:IL-10 is high, does that mean I am TH1 dominant?

Any thoughts?

Thank You!


Dr. Braverman

2026 Posts
RE: Th1 or Th2 Dominant? Posted on: Sep 18, 2013 at 8:18pm
In fact Hashimotos is a TH2 dominant syndrome and is consistant with your elevated CD19/5. Elevated NK cells are also associated with a TH2 environment. Your TNF is borderline at best and INF gamma normal , so this is most in line with a TH2 dominant state. Treatment should be in accordance with this and also based on your clinical history.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.


3 Posts
Reply RE: Th1 or Th2 Dominant? Posted on: Sep 19, 2013 at 12:55am
Really TH2 Dominant? I always thought I was Th1 domniant, but couldn't ever get that verified. I brought back a huge bottle of expensive curcurmin to start taking before my next cycle...but I guess I should avoid that since it is is a Th2 stimulant? Caffeine has always made me feel better which is why I thought I was Th1. Interesting....Even if my NK cells are normal? what about the 50:1 ratios....? Do those impact status? I guess I thought if my TNF were high, then I was TH1 and if my IFN were high I was TH2. My thyroid antibodies have pretty much always been normal..with one of them being just ever so slightly high. Now they are both normal.

Thank you again!