Thin Lining/Celiac Disease?

GingerB

1 Posts
Reply Posted on: Jan 3, 2013 at 5:28pm
Dear Dr. Braverman-
I have seen 3 top RE specialists over the last year to try and figure out what is going on with me. I am 45 and trying to do donor egg- but have had to cancel because of persistent thin lining. I was evaluated for Asherman's Syndrome and had an operative Lysis of Adhesions hysteroscopy in Sept- a very small amount of scar tissue (less than 10%) was removed uterus deemed healthy. Had a follow-up hysteroscopy in November and no scarring was present- everything looked "healthy and pink." Since my uterine lining previously did not respond well with high doses of estrogen patches-suppositories-IM injectables/Viagra/Trental – but it did get close to normal and trilaminar during a gonadotropin stim cycle, we were wondering if perhaps my body just responds differently to exogenous estrogen vs. endogenous estrogen. Does that make sense?

The other frustrating pieces of the puzzle is I have had secondary ammenorea for over 2 years since going off BCP, and, 2 years ago I suddenly presented with severe Celiac Disease and last year hypothyroidism/antythroid antibodies. The thyroid is under control and normal levels of ATAs-and Celiac controlled with strict gluten free diet. I did get the genetic test for celiac and I have HLA Homozygosity for the celiac genes on both alleles, making me particularly sensitive to gluten- and more at risk for refractory celiac disease…..Every wonderful expert I have consulted doesn't know why my lining is persistently thin, OR, if there is a connection to Celiac D. There just isn't much research into this. I am wondering if I may have refractory Celiac and that is why my period has never returned, and my lining is not normal?

We plan to try a mock stim cycle with gonadotropins, and possibly Neupogen. Have you had any

Dr. Braverman

2026 Posts
RE: Thin Lining/Celiac Disease? Posted on: Jan 4, 2013 at 6:11am
I think your message was cut off at the end, however I think that the approach sounds reasoanble to use gonadotropins again and get a high natural estrogen level. I also think a neupogen flush is reasonable as well if you are not able to attain a reasonable lining. There is literature that shows high levels of inflammatory cells can cause uterine artery resistance which can also lead to thin uterine linings(this may be associated with your celiac disease. But if you have had a good lining before on gonadotropins I see no reason why you cant get there again. Good luck.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.