Three miscarriages - CHI Diagnosis


1 Posts
Reply Posted on: Oct 27, 2013 at 6:49am

I have had two first trimester miscarriages (14 and 9 weeks) and one recent stillbirth at 23 weeks. The post mortem from the first miscarriage showed that I had CHI in my placenta. During my last pregnancy I was throughly monitored by a London specialist who prescribed me 25mg prednisolone from ovulation to 16 weeks gestation, 0.40ml clexane daily, intralipids every 4 weeks, vitamin d and the usual prenatal vitamins. (I was told to stop 75mg aspirin after 8 weeks due to a little bleeding).

At the 21 week scan the growth was normal apart from the length of the femurs, which measured 2 weeks behind. By 22 weeks there was no heartbeat.

Our questions are:
- is the above treatment too focused on NK cells. My levels of NK cells were only slightly elevated, but nothing else was found (clotting screen came back clear etc). Is there something we are missing?

- what else can be done, tests and treatment, from an immunology point of view.

Thank you,

Dr. Braverman

2026 Posts
RE: Three miscarriages - CHI Diagnosis Posted on: Oct 29, 2013 at 7:56am
This is not an NK cell problem and more likely related to anti paternal HLA antibodies and more likely the variety that fix complement , these have been associated with second and thrid trimester fetal morbdity and mortatlity . I can check you for these and the treatments are to follow the levels and use prednsione and IVIG. If you would like me to assist you Please fill out a consult form on my webstie if you want my assistance.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.