TNF spikes from 16.3 to 50.0

april

2 Posts
Reply Posted on: Feb 15, 2013 at 8:10pm
Late Nov 2012, my TNF was 16.3 (at rfu). I was carrying a loss pregnancy at the time. (Baby had died but had not yet m/c). I had done 200mg/kg ivig 3 weeks prior.

Now ttc again - This cycle I did ivig (more than 400mg/kg) on cd7, followed by my TNF result of 50.0 at cd14. (Natural cycle - ovulated on cd11.) Results were also from rfu.

Additionally, my IFN went from a low 4.1 in Nov to a more normal 15.6 current cycle. I was told that my Nov number was due to my unspecified autoimmune disease.

Why would this happen? Shouldn't my proper dosing of ivig lower TNF rather than seemingly increase it?

What treatments would you suggest?

I've been told to double my prednisone to 20mg and do another ivig with bfp.

Thanks!

Dr. Braverman

2026 Posts
RE: TNF spikes from 16.3 to 50.0 Posted on: Feb 15, 2013 at 9:33pm
I really need to see your entire history to give you feedback on the TNF changes. I do see wide fluctuations in these cytokines which is why it is so important to look at the entire immune picture as well as history to decide the best treatments. Feel free to call me and we can have a quick free 10 minute chat to reveiw your case and if we can help you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

april

2 Posts
Reply RE: TNF spikes from 16.3 to 50.0 Posted on: Feb 15, 2013 at 9:38pm
Thank you, Dr Braverman -

On the advice of a nutritionist, I have been taking iron complex 200mg/day since December. Looking around online, it seems that excess iron can cause elevated TNF.


Do you think that supplementing iron as I am could lead to elevated TNF?

If that was happening to me, would stopping the iron supplement reduce TNF?


Thanks again!

Dr. Braverman

2026 Posts
RE: TNF spikes from 16.3 to 50.0 Posted on: Feb 15, 2013 at 9:40pm
There are numerous reasons for elevated TNF this is just one, you would need to at least workup all the others to decide which is most likely the cause.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.