27 Years Old w/ Primary Recurrent Pregnancy Loss


1 Posts
Reply Posted on: Feb 6, 2017 at 2:38pm
Hi Dr. Braverman,

My husband and I have been trying to start a family for 2 years now (started at ages 25 and 26). Unfortunately we have been unsuccessful in our attempts and have had 3 consecutive first trimester losses. The first 2 losses were very early. The first loss was a blighted ovum at around 7.5 weeks, and the second I guess was reabsorbed because there was nothing but blood clots on the ultrasound at almost 9 weeks??? The last loss was around 12 weeks (missed miscarriage-the embryo died at 8 weeks, 6 days). I had a D&C with FISH analysis performed, and it was found that the fetus had mosaic Turner Syndrome (Monosomy X). The cause of the first 2 losses are not known.

I have had extensive testing performed; Antiphospholipid antibodies, Factor V, Factor II, prothrombin, progesterone, Day 3 FSH/LH/Estradiol, sonohysterogram with endometrial biopsy to check for structural abnormalities and inflammation/endometritis, and TSH. I have also been tested for various autoimmune diseases ranging from lupus to Hashimotos. My husband has only been tested for infections at this point. My menstrual cycles are pretty regular at 30-34 days with very little cramping. I usually get pregnant within the first 3 cycles.

All testing was normal except for a low positive anticardiolipin antibody level (was tested a second time 6 weeks later and was told it went down to normal levels) and a positive ANA of 1:320. I also have Raynaud's Disease and microscopic colitis, which I know tend to be associated with autoimmune diseases. My current RE is having me take low dose aspirin because of the Raynaud's and one positive anticardiolipin test. He recommends IVF with PGD if we have a fourth loss.

I have read some medical studies regarding the role of oxidative stress in inflammatory diseases and also recurrent pregnancy loss. Do you think it is possible that my recurrent miscarriages, Raynaud's and microscopic colitis can all be linked to oxidative stress? Are there supplements or medications that you can take to reduce oxidative stress? Do you recommend any further testing that can be done on either me or my husband at this point? At only 27 and 28 years old I refuse to believe that we are continuously miscarrying due to just "bad luck".

Thank you for your time,


Dr. Braverman

2026 Posts
RE: 27 Years Old w/ Primary Recurrent Pregnancy Loss Posted on: Feb 6, 2017 at 7:13pm
First I think it is very likely you have silent endometriosis. Your Hashimotos, pos ANA , positive anitphospholipid antibodies and your miscarriages are all c/w with this. Yes you would benefit from anti oxidants ( just buy our supplements and probiotics for endometriosis on our website endooptimimize). You have only had a very limited workup and need a complete immune profile . Fill out a consult form on our website and we will schedule a free phone or SKYPE consult so we can review your case in detail.
Braverman Medical Team
Braverman Reproductive Immunology P.C.