History of Reproductive Immunology

How Was Reproductive Immunology Developed?

Reproductive Immunology originated with the work of Dr. Medewar which began in the 1940s and ultimately earned him the Nobel Prize. Dr. Medewar observed that when an organ was transplanted from the male partner of a female mouse, the organ was immediately rejected unless the female mouse was currently pregnant with that male's fetus, in which case, she did not reject the organ transplant. He also noted that even when pregnant, the female mouse would reject any organ transplant from any male mouse other than that of the father of the embryo she was carrying. This showed that the immune system of the female was able to generate "selective tolerance" to certain genes of the father.

Further research continued to be carried out, based on the obviously significant role of the mother's immune system in accepting an embryo. Today, we know a great deal about the exact workings of the immune system and how it affects a pregnancy. A lot of information has been accumulated regarding defects in the operation of the immune system and how these can result in recurrent miscarriages. Fortunately, this has allowed us to develop treatments that can increase the rate of successful pregnancies for women worldwide.

Dedicated Medical Care to Help with Pregnancy Complications

Unexplained infertility and recurrent pregnancy loss may be one of the most difficult experiences you ever face. Our medical team, led by Dr. Vidali, has extensive experience with reproductive immunology and has had great success helping many couples expand their families. Our Medical Team continues to research and refine techniques in this field, developing testing methods and procedures that provide a greater degree of effectiveness of treatment. We are the only practice that has been authorized to use the name "Reproductive Immunology" in New York State as this requires that we show proof of expertise in both immunology and reproductive medicine to the New York State Department of Education.

If you have questions regarding reproductive immunology or recurrent miscarriage, visit us on our discussion forum!