4 failed Egg Donor cycles

Perla

2 Posts
Reply Posted on: Oct 29, 2014 at 6:40am
Hello Dr Braverman

I am 33 years old, I was diagnosed with POF when I was 28. And also diagnosed with Hypothyreose.

I had 5 egg donor cycles:
1st fresh transfer -> live birth daughter
1st FET transfer -> negative
2nd FET transfer -> positive, spontaneous miscarriage at 6weeks
3rd FET transfer -> positive, missed miscarriage
2nd fresh transfer -> biochemical

Every transfer the lining was triple-layer.

Chicago Immune Tests results:

MTHFR a1298c -> heterozygous

NK Cell Inhibition Panel
50:1 15.1%
25:1 10.6%
12.5:1 8.3%
IVIG 12.5 50:1 4.2%
IVIG 12.5 25:1 2.8%
Intralipid 1.5 mg/ml 50:1 15.3%
Intralipid 1.5 mg/ml 25:1 10.6%

%CD3 79.0%
%CD19 8.0%
%CD56 *12.1% (H) Ref. 2.0 - 12.0
%CD19+cells CD5+ *2.0% (L) Ref. 5.0 – 10.0

TH1:TH2 intracellular cytokine ratios
TNF-a:IL-10 (CD3+CD4+) *33.1 Ref. 13.2 - 30.6
IFN-g:IL-10 (CD3+CD4+) 18.2


Leukocyte Antibody Detection

Flowcytometry Weak Positive
[T-cells] IgM+ 8.8%
[T-cells] IgG+ 42.7%
[B-cells] IgM+ 1.3%
[B-cells] IgG+ 1.0%

KIR Genotyping

Inhibitory 2DL1, 2DL2* 001/2/3/5, 2DL3, 2DL4, 2DL5, 3DL1, 3DL2, 3DL3

Activating 2DS2, 2DS3, 2DS4, 2DS4* deletion Ex.5 , 2DS4* full length

2DS4* full length Ex.5 was previously reported as 2DS4*00101/00102, and 2DS4* deletion Ex5 was previously reported as 2DS4*003/4/6/7/8/9.

DQ Alpha, HiddenC results will follow, all other results (ANA, Karyotype . . ) are normal.


What are your thoughts about these results ? Some of my LAD numbers are very very low. Treatment offered is LIT. I would really like to avoid LIT. Is there another treatment for the low numbers ?

Kind regards

Dr. Braverman

2026 Posts
RE: 4 failed Egg Donor cycles Posted on: Oct 29, 2014 at 9:05am
If you read my blogs you will see I put now value in LAD testing or LIT therapy. Your workup seems to be minimal at best and usually what I see ordered by those practicing reproductive immunology , but wihtout a background in immunology. If you go to my Diagnositic Testing page and Sample reports you will see the work up that you absoultey need based on your history . I would be happy to assist you , simply fill out a consult request from the website and I will arrange a free 10 minute chat to discuss your cases.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Perla

2 Posts
Reply RE: 4 failed Egg Donor cycles Posted on: Oct 30, 2014 at 3:53am
Hello

Thank you for your answer. I filled out the consult request. I live in a country in Europe where I can not do all the tests. For the Chicago Immune tests i went to London. Do you mean I need to do the full HLA-panel ?

Kind regards

Dr. Braverman

2026 Posts
RE: 4 failed Egg Donor cycles Posted on: Oct 30, 2014 at 6:17am
we can arrange to have our testing done for you in Europe, we do this all the time.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.