Egg donor cycle failure with immune treatment

Jamesbubby

5 Posts
Reply Posted on: Dec 29, 2014 at 9:34pm
Hello

I have been diagnosed with 'high' NKC (20 cells per high powered field) and my husband and I share a DQ Alpha partial match of 1.02 and 1.03 gene. I have a history of implantation failure (20+ embryos) and have had an ectopic pregnancy. I have however carried one child to term. Given egg quality concerns I recently completed a donor egg cycle. I transferred one AB hatching blast. My protocol included IVIG and intralipids treatment (7 and 8 days before the FET), 2 cycles of LIT (2 and 3 months before the FET), baby asprin, prednisolone 6 days before the transfer and clexane after the transfer. Yet it still failed. My doctor advised 'there is nothing additional' he can do from an immune perspective and suggested a surrogate may be my only alternative.

My question for you is given the immune treatments I received for this cycle - is there anything additional you think you could do to acheive a successful pregnancy?

If so do I need to complete the full testing offered by your centre or can you advise me based upon my existing tests already performed (in Australia)?

Thank you.

Dr. Braverman

2026 Posts
RE: Egg donor cycle failure with immune treatment Posted on: Dec 31, 2014 at 12:20pm
First of all , in my opinion you have had quite a bit of treatment with minimal testing and no diagnosis. I do not rely at all on uterine NK cells and there is no validity to DQalpha mathcing so there is no wonder they do not know what to do next. I am sure I can help you at least understand what the diagnosis is and then prescribe correct treatement. I do not beleive LIT offers any benefits.
Feel free to fill out a consultation request form so we can schedule a free 10 minute chat.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Jamesbubby

5 Posts
Reply RE: Egg donor cycle failure with immune treatment Posted on: Dec 31, 2014 at 1:19pm
Thanks for your response and happy new year to you!

I'm already booked in for a phone call with you on 12 January and I'm in the process of registering as an immune patient as I agree full testing will be required to get some answers!

I do have one further question - is there any natural supplements you would recommend I start taking now (fish oil, D3)? I feel like I need to do 'something'...

Dr. Braverman

2026 Posts
RE: Egg donor cycle failure with immune treatment Posted on: Dec 31, 2014 at 1:56pm
D3 and omega 3 are almost always usefull.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Jamesbubby

5 Posts
Reply RE: Egg donor cycle failure with immune treatment Posted on: Jan 4, 2015 at 2:38pm
Hello

Thanks for this response.

I've seen you also recommend resveratrol and pycogenol and sometimes vitamin E for patients. Would you recommend I also start taking these supplements, or is it better to await the outcome of the full immune assessment?

Dr. Braverman

2026 Posts
RE: Egg donor cycle failure with immune treatment Posted on: Jan 5, 2015 at 10:46am
I see no harm in starting these supplements before your testing is back , we can always modify if we need to.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.