HLA C significance of matching your partner

Dr. Braverman

2026 Posts
Reply HLA C significance of matching your partner Posted on: Oct 6, 2010 at 4:04pm
New literature confirms what we have already posted on this site. In this issue of Reproductive Immunology researchers have again found that the embryo's HLA C molecule on the surface of its trophoblast must be different than the HLA C molecule on the mothers NK cells. When they are different the NK cells are deactivated , but when they match the NK cells do not get deactivated and attack the embryo. Patients that are complete matches(husband and wife) on the HLA C gene that we test for(everyone has 2 , one from each of thier parents), have always shown evidence of immune rejections which supports this current literature. Fortunately , this problem responds well to immune therapy.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

FutureMommy

0 Posts
Re: HLA C significance of matching your partner Posted on: Oct 7, 2010 at 3:53am
so for those of us that have partial HLA-C matches (as well as other comparable matching issues - if there any) , how far away do you think it is before pre-implantation testing will be regular and affordable to eliminate usage of embryos with matching molecules in IVF cycles?

Dr. Braverman

2026 Posts
Reply Re: HLA C significance of matching your partner Posted on: Oct 7, 2010 at 11:35pm
Although we know that matching HLA C between embryo and mother does not deactivate the NK cells at the Uterine lining, we havent made the jump yet to eliminate matches. I dont think the expense to test for HLA on the embryo(and it can be done) is the major issue. Just that we may loose a few embryos in the process for something that we cant be sure is the only issue. Clearly for someone who wants to take no chances and does not discard a matching embryo , if the embryo survives the biopsy and most do, then it it not an unreasonable choice, not one I recommend at this time. Reprogenetics can give an estimate on the cost of HLA typing fo the embryo, lastly it may require a Day 6 embryo transfer and we dont have as much data on success of Day 6 transfers when the embryo is a hatching blast on Day 5.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Wal

1 Posts
RE: HLA C significance of matching your partner Posted on: Jun 22, 2015 at 9:19pm
Hi Dr.braverman, what type of immune treatment you would use on hla c matching?. Thanks

Dr. Braverman

2026 Posts
Reply RE: HLA C significance of matching your partner Posted on: Jun 23, 2015 at 6:25am
We have since learned that HLA C mathcing may not by itself be a significant issue. The remainder of the HLA profile must be evlauted in cases of failures.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.