HLA match treatment/elevated temperature

Sara

14 Posts
Reply Posted on: Dec 14, 2012 at 3:01am
Good morning Dr.,

I have 2 questions to ask:

1- Is Neupogen only treatment for HLA matches?
2- Last time (4 months ago) when I got a positive pregnancy result and then turned out to be a chemical one, during the 2WW, I felt that I had slightly elevated temperature in my feet and hands. One of the ladies I know who is going through IVF also had the same symptoms and ended in chemical, too.
From your experience, what do you think was the origin of this temperature?
We did not have a flu or something.

Thank you

Dr. Braverman

2026 Posts
RE: HLA match treatment/elevated temperature Posted on: Dec 14, 2012 at 5:54am
There are many reasons for elevated temperature, yes an immune reaction could be one of them. without knowing all of your results and history I could not make a recommendation on the correct treatment. HLA matches are not always this issue and less likely to be when other cuases are indentified. Its also important to know which HLA matches are present that would dictate treatment as well.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Sara

14 Posts
Reply RE: HLA match treatment/elevated temperature Posted on: Dec 18, 2012 at 4:51am
Thank you dr.

Our situation is as following:

1- severe male factor (everything low and abnormal)
2- I have increased TNF and IFN (slightly)
3-HLA matches are:
wife
DQ Alpha (1.1) (1.2)
DQ Beta (05,06)
HLA A (02,03)
HLA B (18,49)
HLA C (07,07)
HLA DRB1; 01, 13, DRB3 present

husband:
DQ Alpha (1.2) (3.1)
DQ Beta (03,06)
HLA A (02,03)
HLA B (51, 51)
HLA C (14, 15)
HLA DRB1; 04, 13, DRB3, DRB4 present

Do we need neupogen for this? What are other possible treatments?
Do you think it would be better to transfer only 1 embryo at a time?

As always, thanks a lot!

Dr. Braverman

2026 Posts
RE: HLA match treatment/elevated temperature Posted on: Dec 18, 2012 at 6:20am
Yes you do have several matches here, but there are still signficant differences between both of you on the Class 2 HLA antigens which may be enough . I would really need to know your entire clinical history and see all of the usual immune parameters before giving you such an important recommendation. I would be happy to assist you with this, feel free to call my office and they will schedule a SKYPE consult for you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.