Intralipids vs Ivig

Jacqui

7 Posts
Reply Posted on: Mar 12, 2014 at 3:56pm
Hi Dr Braverman
i know a lot of studies have shown that intralipids works just as well as Ivig does in supressing NK cell activity. But I have read that Ivig is stronger than intralipids, is this correct? Do intralipids and Ivig work in different ways to protect the embryo? As I was reading on your. Webpage that Ivig acts like shield on the embryo? Does intralipids do this too or differently?
Thanks for your advice
Jacqui
Jacqui

Dr. Braverman

2026 Posts
RE: Intralipids vs Ivig Posted on: Mar 12, 2014 at 9:01pm
While some of the effects of Intralipids and IVIG may be similar(i.e NK cell deactivation and reduction in T cell cytotoxity , there are different mechanisms that acheive this and those mechanisms also give vastly different benefits in different immune situations. Intralipids have found very little use in TH2 (antibody mediated states) and those of elevated inflammatory serum cytokines. IVIG does have the "shield" affect you mention as one of its MANY benefits. IL do not have this benefit. IL is not a "poor" mans IVIG it is a completely different treatment with vastly different indications than IVIG .
there are not "a lot " of studies showing IL works as well as IVIG but this is simply not true when all variables are correctly controlled. IL is a good treatment when used in the proper situations. NK cell elevation is not a "diagnosis" its just a symptom and to determine correct treatment you must find the diagnosis that is causing the NK cell elevation .
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Jacqui

7 Posts
Reply RE: Intralipids vs Ivig Posted on: Mar 12, 2014 at 9:37pm
Great Thankyou. So woukd you have situations where you woukd give your patients both IL and IVIG?
Jacqui

Dr. Braverman

2026 Posts
RE: Intralipids vs Ivig Posted on: Mar 13, 2014 at 6:15am
No , IVIG does all that IL does and a lot more so never a need to overlap.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.