Miscarriage

Mufy

3 Posts
Reply Posted on: Jan 13, 2014 at 4:02am
Dear Dr BravermanI am now 39 years old.I have been trying to get pregnant for the last 3 years.I had en ectopic in 2011I started IVF last year, one failed cycle, one successful cycle which ended with an early miscarriage.I was also diagnosed with a complete septum and was operated a few months ago and had it removed.I have been researching re immunological disorders and have done some tests, which are herewith attached however my doctors could, not really give me an explanation whether I have high NK cells or not.Can you shed some lightThanks and regardsMufy

Mufy

3 Posts
Reply RE: Miscarriage Posted on: Jan 13, 2014 at 6:21am
These are my NK results:

Dr. Braverman

2026 Posts
RE: Miscarriage Posted on: Jan 13, 2014 at 6:33am
I can not open this , Im sorry.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Mufy

3 Posts
Reply RE: Miscarriage Posted on: Jan 13, 2014 at 7:08am
Dr Bravermanl

I have retyped the results

Regards

Mufy



Natural Killer Cells Count

Lymphocyte count (10ˆ9/L) : 3.745
Total NK Cell Absolute count (10ˆ9/L) : 532.6
(Lymphocyte) total NK (%): *14.2
normal range(%): less than 10

NK (dim) Absolute count (10ˆ6/L) : 493.3
(total NK) NK(dim) (%) : 92.6
NK (Bright) Absolute Count (10ˆ6/L) : 39.28
(Total NK) NK (brigh) (%) 7.4

Activation marker of natural killer cells
Total NK CD69 Absolute count (10ˆ6/L) : 2.39
Total NK CD69 (%): 0.45
Normal range: less than 1

NK(dim) CD69 Abolute count: (10ˆ6/L) : 1.53
(Total NK) NK(dim) CD69 (%): 0.29
NK(bright) CD69 Absolute Count (10ˆ6)/L) : 0.86
(Total NK) (bright) CD69 (%): 0.16

NK- CELL CYTOTOXICITY ASSAY
NK cell 50:1 :46%
NK cell 25:1 :27%
NK cell 12.5:1 12%
NK cell 50:1 w/IVIG 12.5mg/ml: 30% Reduction in killing: 35%
NK cell 50:1 w/IVIG 6.25mg/ml: 41% Reduction in killing: 11%
50:1 with Prednisolone 10mg/ml: 18% Reduction in killing: 61%
50:1 with Prednisolone 5mg/ml:23% Reduction in killing: 50%
50:1 with Prednisolone 3mg/ml: 44% Reduction in killing: 4%
50:1 with Prednisolone 1mg/ml: 40% Reduction in killing: 13%

Dr. Braverman

2026 Posts
RE: Miscarriage Posted on: Jan 13, 2014 at 7:40am
Again although it is apparant the NK acitivity is elevated, this is still not enough knowledge by itself to recommend treatment plan.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.