MTHFR and 2 losses

beanpolesmom

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Reply MTHFR and 2 losses Posted on: Aug 11, 2011 at 9:27pm
Dr. Braverman,
Over the past two years, I have have two miscarriages, both around 9-10 weeks. I had seen a heartbeat on both pregnancies around 8 weeks, but was only taking a prenatal with those pregnancies. I found an OB that would test for immune issues and thrombophilias after only two losses and found that I only tested positive for MTHFR and had normal homosysteine levels at the time. I believe it was heterozygous, but I'm not positive. I am almost 6 weeks pregnant now and have been taking BA, extra folic acid, and Neevo for the past few months. I am not sure if I should add the lovenox, considering the MTHFR is my only issue. Current thought (by my OB) is that it may be overkill, but I want to do everything that I can to keep this pregnancy.
I did have a successful pregnancy with no complications 9 years ago, prior to knowing any of this.
Thanks for your help.

Dr. Braverman

2026 Posts
Re: MTHFR and 2 losses Posted on: Aug 12, 2011 at 4:36am
which MTHFR did you have C677 or A12 ? was it homozygous or heterozygous? I think lovenox is never overkill considering your clinical history.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

beanpolesmom

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Reply Re: MTHFR and 2 losses Posted on: Aug 17, 2011 at 1:25am
I have homozygous C677.

beanpolesmom

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Reply Re: MTHFR and 2 losses Posted on: Aug 17, 2011 at 1:28am
I have heard that the homozygous mutation is the most serious of the MTHFR possibilities. Is this true? Also, is there a way to monitor if the dosage of lovenox is working? I have heard there is something called an anti-XA test that can be run.

Dr. Braverman

2026 Posts
Re: MTHFR and 2 losses Posted on: Aug 18, 2011 at 12:46am
Yes you are correct although still not uncommon and not "serious" the homozygous C677 is the most significant of the MTFHR mutations and with a strong clinical history of miscarriage lovenox seems to be the best treatment and yes the heparin anti XA level is the best way to monitor your levels.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.