Multiple Miscarriages

Stephanie Hayes

1 Posts
Reply Posted on: Oct 28, 2013 at 8:51am
Hello,
My husband and I are looking for a RE that could help us keep a pregnancy. I am 28 years old, my husband is 33 and we don't have any trouble getting pregnant (we've been married for 3 years and within the first year and a half of our marriage we had been pregnant three times), but for some unknown reason to us, we can't stay pregnant. With all of my pregnancies the doctor has picked up a heartbeat on the ultrasound machine, and the furthest along I've ever been was 13 weeks, with my first pregnancy. The last two were 8 and 9 weeks along. I had to have 3 D&C's, two within a year, and my reg. OB/GYN has checked for immunological causes, she's checked my ovarian reserves, she's checked chromosomal translocations with both my husband and myself, and every test we've done has come back showing there isn't a problem, except for the MTHFR gene that I have, which isn't even the really bad one, and I'm homogenous for that gene. She ran all these tests after the first miscarriage, and I was put on Lovenox whenever I had a subsequent pregnancy, as well as baby aspirin and an extra dose of folic acid. The second and third pregnancies both ended with one having triploidy and the other having trisomy 18. The first miscarriage, no chromosomal abnormalities were found. At this point, my husband and I are afraid to try because I don't want to go through yet another miscarriage. Do you have any suggestions for patients like myself?
Thank you and God bless,
Stephanie

Dr. Braverman

2026 Posts
RE: Multiple Miscarriages Posted on: Oct 30, 2013 at 6:06am
First the A12C MTFHR has been shown to be associated with chromosomal losses especialy when homozygous and this can be treated with Folic Acid/ B6 and B12 (Metanx is a prescription form of this) . If the normal pregnancy was female you dont know for sure that was normal as it could have been contaminated with your tissue.
The other issue of course is that a "complete" immune workup is necessary including a ful HLA gene alaysisis as well as all cytokine ratios and serum cytokines in the blood. Im sure this has not been done yet.
If you would like me to help you feel free to fill out a consult form on my website and we can schedule a free 10 min chat.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.