No KIR Receptors - 6 weeks pregnant

MandyPandy

2 Posts
Reply Posted on: Mar 22, 2013 at 11:47am
Hi there

I'm wondering if it might be possible to ask for some help please?

I am currently just under 6 weeks pregnant. After many years of IVF with immune therapy, it happened naturally.

I have had my NK's and cytokines tested and they are within normal range.

I had IVIG last week (Weds)

I have just had my KIR receptor results and they show that all three receptors are missing. The results are:

Inhibitory:

2DL1
2DL3
2DL4
3DL1
3DL2
3DL3

Activating:

2DS4*00103
2DS4*003/4/6/7/8/9
2DS4*00101/00102

I am being prescribed neupogen and will start taking it tomorrow.

My question is whether it is too late to take it?

I am hoping the IVIG will help (I also have low LAD so will be having LIT on Monday as well) but wondered whether there is any point in doing the neupogen or if it really needs to be taken before becoming pregnant - but as I say, my NK's and cytokines are normal (before any form of immune therapy).

Dr. Braverman

2026 Posts
RE: No KIR Receptors - 6 weeks pregnant Posted on: Mar 22, 2013 at 12:27pm
I would want to know your entire HLA C / KIR numbers to better answer this question. although when needed neupogen is best started early I have had success starting it late. Not sure why you need LIT? low LAD alone is not enough to make this decision unless you have been pregnant at least once before and gone to the third trimester. I would need to review your enitre history to answer most of these questions. I would be happy to squeeze you in urgently if you would like a full consutlation on this .
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

MandyPandy

2 Posts
Reply RE: No KIR Receptors - 6 weeks pregnant Posted on: Mar 22, 2013 at 12:30pm
I forgot to mention that this is my first ever natural pregnancy.

I have Hashimoto's but due to an egg free, gluten free, dairy free (and much reduced sugar) diet, my anti thyroglobulin antibodies are now in the normal range and my Anti TPO's are greatly reduced, which is why I think this pregnancy happened in the first place.