Prednisone, Doxycycline and IVIg?


1 Posts
Reply Posted on: Jun 26, 2013 at 11:00pm
Hello Dr Braverman

I am writing from Australia. I have had two miscarriages at 7 weeks and one chemical pregnancy. For my last IVF cycle, my doctor put me on prednisone, doxycycline and IVIg. There was no pregnancy resulting. This cycle I'm with a new doctor and he does not think I need all that. I have IVIg booked for Day 6, but should I also take prednisone and doxycycline? I am on Day 3 of my cycle now and am feeling confused.

My history is that I have done a broad range of tests. All blood tests have been normal - ANA/Lupus/thyroid etc. The only indications of immune issuesare from:

Chicago bloods
- CD19 at 12.2 (range 2-12)
- TNF-a:IL-10 at 35.1 (range 13.2-30.6)
- Dr said LAD levels low (negative / 1.0 / 1.4 / 2.5 / 2.7)

Endometrial biopsy
- CD 56 - mean 71, range 50-102
- CD 57 - mean 1.5, range 0-3

I would greatly appreciate any suggestions you may have as to whether IVIg is sufficient or whether you believe I should take prednisone and doxycycline as well.

Kind regards


Dr. Braverman

2026 Posts
RE: Prednisone, Doxycycline and IVIg? Posted on: Jun 27, 2013 at 10:25am
I think the workup is still very incomplete , the levels are not that high on the TNF and you havent looked at the HLA status of you and your husband , cytokine production from your NK , NKT or CD8+ cells, at a minimum you need these to determine the reaons for the failures. I would be happy to assist you and can get the testing done for you from Australia. I follow many paitents there.
If you would like my assistance simply fill out the consultation form on the website. To guide you on your treatments based on the results you have had to date is not possilbe to do with any level of certianty.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.