Chemokines on T cells risk for miscarriage

Posted By Braverman IVF & Reproductive Immunology || 21-Sep-2010

All sounds complicated but to summarize this , it means that it may be a more accurate assessment of a patients risk for immune rejection to not look at the amount of cytokine being produced but to look at how many of the TH1 producing cells are there with chemokines on their surface because those are the cells that will go to the uterine lining to interfere with implantation. Remember we need to get the best assessment from the blood tests as to what is happening at the implantation site.

This study showed that when T cells have a greater number of TH1 chemokine receptors (and these are only on TH1 producing cells) than TH2 chemokine receptors (only on TH2 producing cells) then there was a much greater chance of miscarriage. Its the chemokine receptors reacting to the chemokines sent from the uterine lining that have those T cells go to the uterine lining.

We can test for these receptors now and Im going to look at the cost it adds to the immune panel as of course we have to keep those costs under control.

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