Omega 3-Optimize Offers a Natural Approach to restore optimal fatty acid profile, reduce your inflammation, improve your egg and sperm quality and support your pregnancy.

Posted By Braverman IVF & Reproductive Immunology || 31-Jan-2018

Our latest supplement "Omega 3- Optimize" is now available

Omega 3-Optimize: What is it?

Omega 3-Optimize is the latest addition to our supplement family. It is made from extremely purified EPA and DHA in the form of triglyceride, the most deliverable form of omega 3s. Indeed, there are two different forms of omega 3 in the market, either available in ethyl ester form (EE) or triglyceride form (TG). They differ based on the method of esterification, process during which fatty acids are added to an ethanol backbone for the ethyl ester form or to a glycerol backbone for the triglyceride form. During digestion, an enzyme (pancreatic lipase) hydrolyses EE to a lesser extent than TG and at a slower rate leading to higher TG bioavailability.

Our formulation displays the highest concentration of EPA and DHA with 1000 mg per soft gel. Our product is gluten-free and contains non-GMO components. It is manufactured by Neptune Wellness Solutions, proud member of the GOED (Global organization for EPA and DHA omega 3s) whose focus is quality and purity of the omega 3s with strict quality and ethics standards at every step of the production. GOED members are randomly tested and consistently pass all the requirements necessary to meet the GOED standards, stricter than any single regulation in the world!

Omega-3 optimize is analyzed by an independent, third-party laboratory to check its purity and if all label claims are met. Omega-3 Optimize is IFOS- 5 stars certified (highest level of certification) and you can now instantly access our certificate of analysis by scanning the QR code on the bottle!

How Omega 3-Optimize May Help?

Minimizing maternal inflammation, improving oocyte quality and beneficial impact during pregnancy in female patients

A healthy pregnancy switches the maternal immune system toward a more tolerant, low inflammatory state. Many autoimmune diseases or other conditions such as PCOS or endometriosis may lead to systemic inflammation and oxidative stress negatively impacting oocyte/embryo quality and may be involved in infertility and recurrent pregnancy loss (RPL). Similarly, leptin (a marker of follicle hypoxia leading to oxidative stress in the oocyte) whose serum concentration is related to the amount of adipose tissue (1) can severely impact the quality of your oocyte (gamete) by disrupting:

  • Follicle growth with reduced number of mature oocytes (2)
  • Leading to poor embryo development (3)
  • Leading to reduced rate of embryo implantation (4)

    An increased ω3 intake prior to conception was shown to positively impact embryo morphology in a study on women undergoing IVF cycle (5). ω3 appear to promote vascular development in the endometrium as seen by in vitro study (6). Many other studies showed that a higher ω3 intake:

  • can reduce leptin levels (7) thus improving your oocyte/embryo quality
  • can reduce the risk of miscarriage (8).
  • Increase uterine blood flow (9)
  • Increase the length of pregnancy and reduce preterm birth (10).
  • Reduce placental inflammation when taking during the first trimester and through the pregnancy (11).

    The figure below can summarize how ω3 can help reduce maternal inflammation/ oxidative stress (12).

    Omega 3 fatty acid directly act on placenta to increase anti-oxidant production that will counteract the effects of reactive oxygen species (ROS).   

    Resolvins and protectins (products of DHA and EPA metabolism) can reduce placental PGE2 (the prostaglandin associated with parturition) and reduce placental inflammation. Altogether, these effects can reduce the risk of pregnancy losses or complications.

    Figure 1: Summary of ω3 pleiotropic effects on maternal/placental inflammation

    For more information, read our blog on the topic: No benefit found with Intralipid Therapy. Ground Breaking New Study from BRI.

    Minimizing paternal inflammation, improving sperm parameters (quantity and quality) and reducing sperm DNA fragmentation in male patient

    Male infertility is due to low sperm production, abnormal sperm function or blockages that prevent the delivery of sperm.

    A recent meta-analyze (13) involving almost 43,000 fertile men showed a dramatic decrease in the concentration of sperm of men from western countries dropping to -52% over a 40 years period. In addition, a higher rate of sperm abnormal morphology has been widely described and is a main concern.

    Regardless the potential causes that are multiple and could be attributed to obesity, stress, chemical and electromagnetic exposures, they all lead to endocrine disruption and detrimental reproductive effects such as sperm DNA damage that correlates with:

  • abnormal spermatozoa morphology (14)
  • reduced spermatozoa motility (15)
  • dysregulated acrosome reaction (activation of the spermatozoa in contact to the oocyte)
  • disrupted sperm–oocyte recognition and fusion (16)
  • reduced chances for the fertilization to occur to form an embryo.

    Many studies showed that Omega 3 levels in sperm correlate with serum levels and can be modulated by dietary omega 3 (EPA+DHA) supplementation to increase male fertility through improvement of:

  • Sperm vitality
  • Sperm motility
  • Sperm morphology

    These beneficial impacts are modulated through:

  • A reduction of systemic inflammation
  • A reduction in sperm oxidative stress as seen by reduced ROS levels
  • An increase in anti-oxidant concentration
  • A reduction in sperm DNA damage.

    For more information on how omega 3 supplement can help optimizing your semen parameters, read our blog on the topic: Dietary fish oil can positively impact sperm parameters and improve male fertility.

    < Questions? Call 516.584.8710
    We would be happy to help answer any questions you may have about our Omega 3-Optimize supplement


    1. Budak E, Fernández Sánchez M, Bellver J, Cerveró A, Simón C, Pellicer A. Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil Steril. 2006 Jun;85(6):1563-81. Review.

    2. Anifandis G, Koutselini E, Stefanidis I, Liakopoulos V, Leivaditis C, Mantzavinos T, Vamvakopoulos N. Serum and follicular fluid leptin levels are correlated with human embryo quality. Reproduction. 2005 Dec;130(6):917-21.

    3. Kawamura K, Sato N, Fukuda J, Kodama H, Kumagai J, Tanikawa H, Nakamura A, Tanaka T. Leptin promotes the development of mouse preimplantation embryos in vitro. Endocrinology. 2002 May;143(5):1922-31.

    4. Castellucci M, De Matteis R, Meisser A, Cancello R, Monsurrò V, Islami D, Sarzani R, Marzioni D, Cinti S, Bischof P. Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion. Mol Hum Reprod. 2000 Oct;6(10):951-8.

    5. Hammiche F, Vujkovic M, Wijburg W, de Vries JH, Macklon NS, Laven JS, Steegers-Theunissen RP. Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology

    6. Johnsen GM, Basak S, Weedon-Fekjær MS, Staff AC, Duttaroy AK. Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. Placenta. 2011 Sep;32(9):626-32.

    7. Hariri M, Ghiasvand R, Shiranian A, Askari G, Iraj B, Salehi-Abargouei A. Does omega-3 fatty acids supplementation affect circulating leptin levels? Asystematic review and meta-analysis on randomized controlled clinical trials. Clin Endocrinol (Oxf). 2015 Feb;82(2):221-8.

    8. Di Cintio E, Parazzini F, Chatenoud L, Surace M, Benzi G, Zanconato G, La Vecchia C. Dietary factors and risk of spontaneous abortion. Eur J Obstet Gynecol Reprod Biol. 2001 Mar;95(1):132-6.

    9. Lazzarin N, Vaquero E, Exacoustos C, Bertonotti E, Romanini ME, Arduini D. Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion. Fertil Steril. 2009 Jul;92(1):296-300.

    10. Olsen SF, Sørensen JD, Secher NJ, Hedegaard M, Henriksen TB, Hansen HS, Grant A. Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet. 1992 Apr 25;339(8800):1003-7.

    11. Haghiac M, Yang XH, Presley L, Smith S, Dettelback S, Minium J, Belury MA, Catalano PM, Hauguel-de Mouzon S. Dietary Omega-3 Fatty Acid Supplementation Reduces Inflammation in Obese Pregnant Women: A Randomized Double-Blind Controlled Clinical Trial. PLoS One. 2015 Sep 4;10(9): e0137309.

    12. Leghi GE, Muhlhausler BS. The effect of n-3 LCPUFA supplementation on oxidative stress and inflammation in the placenta and maternal plasma during pregnancy. Prostaglandins Leukot Essent Fatty Acids. 2016 Oct; 113:33-39.

    13. Levine H, Jørgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I, Pinotti R, Swan SH. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update. 2017 Nov 1;23(6):646-659.

    14. Larson-Cook KL, Brannian JD, Hansen KA, Kasperson KM, Aamold ET, Evenson DP. Relationship between the outcomes of assisted reproductive techniques and sperm DNA fragmentation as measured by the sperm chromatin structure assay. Fertil Steril 2003; 80: 895-902.

    15. Giwercman A, Richthoff J, Hjøllund H, Bonde JP, Jepson K, Frohm B, et al. Correlation between sperm motility and sperm chromatin structure assay parameters. Fertil Steril 2003; 80: 1404-1412.

    16. Agarwal A, Saleh RA, Bedaiwy MA 2003. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertility and Sterility 79, 829–843.

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